Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts

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dc.contributor.authorDoughty, Tyler W.
dc.contributor.authorDomenzain, Ivan
dc.contributor.authorMillan-Oropeza, Aaron
dc.contributor.authorMontini, Noemi
dc.contributor.authorde Groot, Philip A.
dc.contributor.authorPereira, Rui
dc.contributor.authorNielsen, Jens
dc.contributor.authorHenry, Celine
dc.contributor.authorDaran, Jean-Marc G.
dc.contributor.authorSiewers, Verena
dc.contributor.authorMorrissey, John P.
dc.contributor.funderHorizon 2020en
dc.date.accessioned2022-03-15T10:00:43Z
dc.date.available2022-03-15T10:00:43Z
dc.date.issued2020-12
dc.date.updated2022-03-14T15:58:48Z
dc.description.abstractThe Saccharomycotina subphylum (budding yeasts) spans 400 million years of evolution and includes species that thrive in diverse environments. To study niche-adaptation, we identify changes in gene expression in three divergent yeasts grown in the presence of various stressors. Duplicated and non-conserved genes are significantly more likely to respond to stress than genes that are conserved as single-copy orthologs. Next, we develop a sorting method that considers evolutionary origin and duplication timing to assign an evolutionary age to each gene. Subsequent analysis reveals that genes that emerged in recent evolutionary time are enriched amongst stress-responsive genes for each species. This gene expression pattern suggests that budding yeasts share a stress adaptation mechanism, whereby selective pressure leads to functionalization of young genes to improve growth in adverse conditions. Further characterization of young genes from species that thrive in harsh environments can inform the design of more robust strains for biotechnology.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDoughty, T. W.,Domenzain, I., Millan-Oropeza, A., Montini, N., de Groot, P. A., Pereira, R., Nielsen, J., Henry, C., Daran, J-M. G., Siewers, V., Morrissey, J. P. (2020) 'Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts', Nature Communications, 11, 2144 (9pp). doi: 10.1038/s41467-020-16073-3en
dc.identifier.doi10.1038/s41467-020-16073-3en
dc.identifier.endpage9en
dc.identifier.issn2041-1723
dc.identifier.journaltitleNature Communicationsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/12929
dc.identifier.volume11en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/720824/EU/Model-Based Construction And Optimisation Of Versatile Chassis Yeast Strains For Production Of Valuable Lipid And Aromatic Compounds/CHASSYen
dc.rights© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectSaccharomycotina subphylumen
dc.subjectBudding yeastsen
dc.subjectNiche-adaptationen
dc.subjectDivergent yeastsen
dc.subjectStress-induced expressionen
dc.subjectEvolutionarily young genesen
dc.subjectDiverse budding yeastsen
dc.titleStress-induced expression is enriched for evolutionarily young genes in diverse budding yeastsen
dc.typeArticle (peer-reviewed)en
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