Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts

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s41467-020-16073-3.pdf(1.34 MB)
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2020-12
Authors
Doughty, Tyler W.
Domenzain, Ivan
Millan-Oropeza, Aaron
Montini, Noemi
de Groot, Philip A.
Pereira, Rui
Nielsen, Jens
Henry, Celine
Daran, Jean-Marc G.
Siewers, Verena
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Nature Publishing Group
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10.1038/s41467-020-16073-3
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Abstract
The Saccharomycotina subphylum (budding yeasts) spans 400 million years of evolution and includes species that thrive in diverse environments. To study niche-adaptation, we identify changes in gene expression in three divergent yeasts grown in the presence of various stressors. Duplicated and non-conserved genes are significantly more likely to respond to stress than genes that are conserved as single-copy orthologs. Next, we develop a sorting method that considers evolutionary origin and duplication timing to assign an evolutionary age to each gene. Subsequent analysis reveals that genes that emerged in recent evolutionary time are enriched amongst stress-responsive genes for each species. This gene expression pattern suggests that budding yeasts share a stress adaptation mechanism, whereby selective pressure leads to functionalization of young genes to improve growth in adverse conditions. Further characterization of young genes from species that thrive in harsh environments can inform the design of more robust strains for biotechnology.
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Keywords
Saccharomycotina subphylum , Budding yeasts , Niche-adaptation , Divergent yeasts , Stress-induced expression , Evolutionarily young genes , Diverse budding yeasts
Citation
Doughty, T. W.,Domenzain, I., Millan-Oropeza, A., Montini, N., de Groot, P. A., Pereira, R., Nielsen, J., Henry, C., Daran, J-M. G., Siewers, V., Morrissey, J. P. (2020) 'Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts', Nature Communications, 11, 2144 (9pp). doi: 10.1038/s41467-020-16073-3
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https://hdl.handle.net/10468/12929
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Microbiology - Journal Articles
APC Microbiome Ireland - Journal Articles
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© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.