Making sense of quorum sensing at the intestinal mucosal interface

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dc.contributor.authorUhlig, Friederikeen
dc.contributor.authorHyland, Niall P.en
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020en
dc.date.accessioned2023-06-01T13:25:53Z
dc.date.available2023-06-01T13:25:53Z
dc.date.issued2022-05-24T00:00:00Zen
dc.description.abstractThe gut microbiome can produce metabolic products that exert diverse activities, including effects on the host. Short chain fatty acids and amino acid derivatives have been the focus of many studies, but given the high microbial density in the gastrointestinal tract, other bacterial products such as those released as part of quorum sensing are likely to play an important role for health and disease. In this review, we provide of an overview on quorum sensing (QS) in the gastrointestinal tract and summarise what is known regarding the role of QS molecules such as auto-inducing peptides (AIP) and acyl-homoserine lactones (AHL) from commensal, probiotic, and pathogenic bacteria in intestinal health and disease. QS regulates the expression of numerous genes including biofilm formation, bacteriocin and toxin secretion, and metabolism. QS has also been shown to play an important role in the bacteria-host interaction. We conclude that the mechanisms of action of QS at the intestinal neuro-immune interface need to be further investigated.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1734en
dc.identifier.citationUhlig, F. and Hyland, N. P. (2022) 'Making sense of quorum sensing at the intestinal mucosal interface', Cells, 11(11), 1734 (20pp). doi: 10.3390/cells11111734en
dc.identifier.doi10.3390/cells11111734en
dc.identifier.eissn35681429en
dc.identifier.endpage20en
dc.identifier.issued11en
dc.identifier.journaltitleCellsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14538
dc.identifier.volume11en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 2/12/RC/2273_P2/IE/APC_Phase 2/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.rights© 2022, the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAHLen
dc.subjectEnteric nervous systemen
dc.subjectIntestinal diseaseen
dc.subjectIntestinal epitheliumen
dc.subjectMicrobiomeen
dc.titleMaking sense of quorum sensing at the intestinal mucosal interfaceen
dc.typeArticle (peer-reviewed)en
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