Bacteriocins: antibiotics in the age of the microbiome

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dc.contributor.authorEgan, Kevin
dc.contributor.authorRoss, R. Paul
dc.contributor.authorHill, Colin
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2017-09-14T13:37:48Z
dc.date.available2017-09-14T13:37:48Z
dc.date.issued2017-04-07
dc.description.abstractAntibiotics have revolutionised the treatment of infectious disease and improved the lives of billions of people worldwide over many decades. With the rise in antimicrobial resistance (AMR) and corresponding lack of antibiotic development, we find ourselves in dire need of alternative treatments. Bacteriocins are a class of bacterially produced, ribosomally synthesised, antimicrobial peptides that may be narrow or broad in their spectra of activity. Animal models have demonstrated the safety and efficacy of bacteriocins in treating a broad range of infections; however, one of the principal drawbacks has been their relatively narrow spectra when compared with small-molecule antibiotics. In an era where we are beginning to appreciate the role of the microbiota in human and animal health, the fact that bacteriocins cause much less collateral damage to the host microbiome makes them a highly desirable therapeutic. This review makes a case for the implementation of bacteriocins as therapeutic antimicrobials, either alone or in combination with existing antibiotics to alleviate the AMR crisis and to lessen the impact of antibiotics on the host microbiome.en
dc.description.sponsorshipDepartment of Agriculture, Food and the Marine (Irish Government under the National Development Plan, through the Food Institutional Research Measure, administered by Department of Agriculture, Fisheries and Food, Ireland (DAFM 13/F/462); Science Foundation Ireland (SFI Investigator awards (10/IN.1/B3027) and the APC Microbiome institute under Grant Number SFI/12/RC/2273)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationEgan, K., Ross, R. P. and Hill, C. (2017) 'Bacteriocins: antibiotics in the age of the microbiome', Emerging Topics in Life Sciences, 1(1), pp. 55-63. doi: 10.1042/etls20160015en
dc.identifier.doi10.1042/etls20160015
dc.identifier.endpage63en
dc.identifier.issn2397-8554
dc.identifier.issn2397-8562
dc.identifier.issued1en
dc.identifier.journaltitleEmerging Topics in Life Sciencesen
dc.identifier.startpage55en
dc.identifier.urihttps://hdl.handle.net/10468/4697
dc.identifier.volume1en
dc.language.isoenen
dc.publisherPortland Pressen
dc.rights© 2017 The Authors; published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biologyen
dc.subjectAntibioticen
dc.subjectAntimicrobial resistanceen
dc.subjectBacteriocinen
dc.subjectMicrobiomeen
dc.subjectProbioticen
dc.titleBacteriocins: antibiotics in the age of the microbiomeen
dc.typeArticle (peer-reviewed)en
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