More than just a number: the gut microbiota and brain function across the extremes of life

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dc.contributor.authorNuzum, Nathan D.en
dc.contributor.authorDeady, Claraen
dc.contributor.authorKittel-Schneider, Sarahen
dc.contributor.authorCryan, John F.en
dc.contributor.authorO'Mahony, Siobhain M.en
dc.contributor.authorClarke, Gerarden
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2025-01-16T12:22:49Z
dc.date.available2025-01-16T12:22:49Z
dc.date.issued2024en
dc.description.abstractUnderstanding the interrelationship between the gut microbiota and host physiology, although still in its relative infancy, has taken important steps forward over the past decade. In the context of brain disorders including those characterized by neurodevelopmental and neurodegenerative changes there have been important advances. However, initially research involved correlational analyses, had limited translational scope, and lacked functional assessments. Thus, largescale longitudinal clinical investigations that assess causation and underlying mechanisms via in depth analysis methods are needed. In neurodegeneration research, strong causal evidence now links the gut microbiome to Alzheimer's (AD), and Parkinson's Disease (PD), as supported by human-to-animal transplantation studies. Longitudinal interventions are being conducted in AD, PD, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis. Neurodevelopmental research has also seen a boon in microbiome-related clinical research including in autism, Attention-deficit/hyperactivity disorder, and schizophrenia, which is confirming prior animal model work regarding the key time-windows in the gut microbiome important for infant cognition. While recent research advances represent important progress, fundamental knowledge gaps and obstacles remain. Knowing how and why the gut microbiome changes at the extremes of life will develop our mechanistic understanding and help build the evidence base as we strive toward counteracting microbial missteps with precision therapeutic interventions.en
dc.description.sponsorshipScience Foundation Ireland (Grant Numbers SFI/12/RC/2273-P2)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2418988en
dc.identifier.citationNuzum, N.D., Deady, C., Kittel-Schneider, S., Cryan, J.F., O’Mahony, S.M. and Clarke, G. (2024) ‘More than just a number: the gut microbiota and brain function across the extremes of life’, Gut Microbes, 16(1), 2418988 (42pp). https://doi.org/10.1080/19490976.2024.2418988en
dc.identifier.doihttps://doi.org/10.1080/19490976.2024.2418988en
dc.identifier.eissn1949-098en
dc.identifier.endpage42en
dc.identifier.issn1949-0976en
dc.identifier.issued1en
dc.identifier.journaltitleGut Microbesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/16838
dc.identifier.volume16en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urihttps://www.tandfonline.com/doi/full/10.1080/19490976.2024.2418988en
dc.rights© 2024, the Author(s). Published with license by Taylor & Francis Group, LLC.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), whichpermits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has beenpublished allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/)en
dc.subjectNeurodevelopmenten
dc.subjectNeurodegenerationen
dc.subjectGut bacteriaen
dc.subjectGut-brain-axisen
dc.subjectEarly-lifeen
dc.subjectOlder adulten
dc.titleMore than just a number: the gut microbiota and brain function across the extremes of lifeen
dc.typeArticle (peer-reviewed)en
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