Akkermansia muciniphila in infectious disease: A new target for this next-generation probiotic?

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dc.contributor.authorKeane, Jonathan M.en
dc.contributor.authorCazzaniga, Monicaen
dc.contributor.authorGahan, Cormac G. M.en
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020en
dc.date.accessioned2025-02-05T10:22:05Z
dc.date.available2025-02-05T10:22:05Z
dc.date.issued2024-03-15en
dc.description.abstractThe common gastrointestinal commensal Akkermansia muciniphila is a mucin-degrading bacterium that is greatly reduced in individuals consuming a high-fat diet. Increasing evidence from a variety of clinical and pre-clinical studies suggests that oral supplementation with Akkermansia can improve metabolic health and moderate systemic inflammation. We and others have demonstrated a role for Akkermansia administration in protection against infectious disease and the outcome from sepsis. Very recent studies have indicated the molecular mechanisms by which A. muciniphila may interact with the host to influence systemic immune-regulation and control of microbial pathogenesis. Here we consider recent studies which demonstrate the efficacy of this potential next-generation probiotic in animal models of Salmonella Typhimurium, Listeria monocytogenes and Clostridioides difficile as well as influenza virus and phlebovirus. The potential mechanisms by which A. muciniphila may influence local and systemic immune responses are discussed.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKeane, J. M., Cazzaniga, M., Gahan, C. G. M. (2024) 'Akkermansia muciniphila in infectious disease: A new target for this next-generation probiotic?', Science Progress, 107(1), pp. 1-7. https://doi.org/10.1177/0036850424123115en
dc.identifier.doihttps://doi.org/10.1177/0036850424123115en
dc.identifier.eissn2047-7163en
dc.identifier.endpage7en
dc.identifier.issn0036-8504en
dc.identifier.issued1en
dc.identifier.journaltitleScience Progressen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/16968
dc.identifier.volume107en
dc.language.isoenen
dc.publisherSAGE Publishingen
dc.relation.ispartofScience Progressen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-ITN-ETN/956279/EU/Colonization resistance: training and research towards microbiome derived solutions to foodborne disease/COL_RESen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Investigator Programme/16/IA/4445/IE/Pharmaceutical and nutraceutical targeting of the farnesoid X receptor for treatment of chroinc intestinal diseases/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 2/12/RC/2273_P2/IE/APC_Phase 2/en
dc.rights© 2024, the Authors. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAkkermansia muciniphilaen
dc.subjectInfectionen
dc.subjectSepsisen
dc.subjectInflammationen
dc.subjectListeriaen
dc.titleAkkermansia muciniphila in infectious disease: A new target for this next-generation probiotic?en
dc.typeArticle (peer-reviewed)en
oaire.citation.issue1en
oaire.citation.volume107en
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