Microbiota‐gut‐brain axis as a regulator of reward processes
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Date
2020-12-25
Authors
García-Cabrerizo, Rubén
Carbia, Carina
O´Riordan, Kenneth J.
Schellekens, Harriet
Cryan, John F.
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons, Inc.
Published Version
Abstract
Our gut harbours trillions of microorganisms essential for the maintenance of homeostasis and host physiology in health and disease. In the last decade, there has been a growing interest in understanding the bidirectional pathway of communication between our microbiota and the central nervous system. With regard to reward processes there is accumulating evidence from both animal and human studies that this axis may be a key factor in gating reward valence. Focusing on the mesocorticolimbic pathway, we will discuss how the intestinal microbiota is involved in regulating brain reward functions, both in natural (i.e. eating, social or sexual behaviours) and non-natural reinforcers (drug addiction behaviours including those relevant to alcohol, psychostimulants, opioids and cannabinoids). We will integrate preclinical and clinical evidence suggesting that the microbiota-gut-brain axis could be implicated in the development of disorders associated with alterations in the reward system and how it may be targeted as a promising therapeutic strategy.
Description
Keywords
Microbiota-gut-brain axis , Reward system , Therapeutic strategy , Drug addiction , Food behaviour , Psychiatric disorders , Reward , Social behaviour
Citation
García-Cabrerizo, R., Carbia, C., O´Riordan, K. J., Schellekens, H. and Cryan, J. F. (2020) 'Microbiota-gut-brain axis as a regulator of reward processes', Journal of Neurochemistry, 157(5), pp. 1495-1524. doi: 10.1111/jnc.15284
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Copyright
© 2020, International Society for Neurochemistry. Published by John Wiley & Sons, Inc. This is the peer reviewed version of the following item: García-Cabrerizo, R., Carbia, C., O´Riordan, K. J., Schellekens, H. and Cryan, J. F. (2020) 'Microbiota-gut-brain axis as a regulator of reward processes', Journal of Neurochemistry, 157(5), pp. 1495-1524, doi: 10.1111/jnc.15284, which has been published in final form at https://doi.org/10.1111/jnc.15284. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.