Microbiota‐gut‐brain axis as a regulator of reward processes

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dc.contributor.authorGarcía-Cabrerizo, Rubénen
dc.contributor.authorCarbia, Carinaen
dc.contributor.authorO´Riordan, Kenneth J.en
dc.contributor.authorSchellekens, Harrieten
dc.contributor.authorCryan, John F.en
dc.contributor.funderHorizon 2020en
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2023-08-08T12:06:25Z
dc.date.available2023-08-08T12:06:25Z
dc.date.issued2020-12-25en
dc.description.abstractOur gut harbours trillions of microorganisms essential for the maintenance of homeostasis and host physiology in health and disease. In the last decade, there has been a growing interest in understanding the bidirectional pathway of communication between our microbiota and the central nervous system. With regard to reward processes there is accumulating evidence from both animal and human studies that this axis may be a key factor in gating reward valence. Focusing on the mesocorticolimbic pathway, we will discuss how the intestinal microbiota is involved in regulating brain reward functions, both in natural (i.e. eating, social or sexual behaviours) and non-natural reinforcers (drug addiction behaviours including those relevant to alcohol, psychostimulants, opioids and cannabinoids). We will integrate preclinical and clinical evidence suggesting that the microbiota-gut-brain axis could be implicated in the development of disorders associated with alterations in the reward system and how it may be targeted as a promising therapeutic strategy.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGarcía-Cabrerizo, R., Carbia, C., O´Riordan, K. J., Schellekens, H. and Cryan, J. F. (2020) 'Microbiota-gut-brain axis as a regulator of reward processes', Journal of Neurochemistry, 157(5), pp. 1495-1524. doi: 10.1111/jnc.15284en
dc.identifier.doi10.1111/jnc.15284en
dc.identifier.eissn1471-4159en
dc.identifier.endpage1524en
dc.identifier.issn0022-3042en
dc.identifier.issued5en
dc.identifier.journaltitleJournal of Neurochemistryen
dc.identifier.startpage1495en
dc.identifier.urihttps://hdl.handle.net/10468/14795
dc.identifier.volume157en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 2/12/RC/2273_P2/IE/APC_Phase 2/en
dc.rights© 2020, International Society for Neurochemistry. Published by John Wiley & Sons, Inc. This is the peer reviewed version of the following item: García-Cabrerizo, R., Carbia, C., O´Riordan, K. J., Schellekens, H. and Cryan, J. F. (2020) 'Microbiota-gut-brain axis as a regulator of reward processes', Journal of Neurochemistry, 157(5), pp. 1495-1524, doi: 10.1111/jnc.15284, which has been published in final form at https://doi.org/10.1111/jnc.15284. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectMicrobiota-gut-brain axisen
dc.subjectReward systemen
dc.subjectTherapeutic strategyen
dc.subjectDrug addictionen
dc.subjectFood behaviouren
dc.subjectPsychiatric disordersen
dc.subjectRewarden
dc.subjectSocial behaviouren
dc.titleMicrobiota‐gut‐brain axis as a regulator of reward processesen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue5en
oaire.citation.volume157en
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