Cocrystallization of nutraceuticals

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dc.contributor.authorSinha, Abhijeet S.
dc.contributor.authorMaguire, Anita R.
dc.contributor.authorLawrence, Simon E.
dc.date.accessioned2018-06-06T11:23:28Z
dc.date.available2018-06-06T11:23:28Z
dc.date.issued2014-12-19
dc.date.updated2018-06-06T10:03:22Z
dc.description.abstractCocrystallization has emerged over the past decade as an attractive technique for modification of the physicochemical properties of compounds used as active pharmaceutical ingredients (APIs), complementing more traditional methods such as salt formation. Nutraceuticals, with associated health benefits and/or medicinal properties, are attractive as coformers due to their ready availability, known pharmacological profile, and natural origin, in addition to offering a dual therapy approach. Successful studies of favorably altering the physicochemical properties of APIs through cocrystallization with nutraceuticals are highlighted in this review. Many of the key functional groups commonly seen in nutraceuticals (e.g., acids, phenols) underpin robust supramolecular synthons in crystal engineering. This review assesses the structural data available to date across a diverse range of nutraceuticals, both in pure form and in multicomponent materials, and identifies the persistent supramolecular features present. This insight will ultimately enable predictive and controlled assembly of functional materials incorporating nutraceuticals together with APIs.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSinha, A. S., Maguire, A. R. and Lawrence, S. E. (2015) 'Cocrystallization of Nutraceuticals', Crystal Growth & Design, 15(2), pp. 984-1009. doi: 10.1021/cg501009cen
dc.identifier.doi10.1021/cg501009c
dc.identifier.endpage1009en
dc.identifier.issn1528-7483
dc.identifier.issued2en
dc.identifier.journaltitleCrystal Growth & Designen
dc.identifier.startpage984en
dc.identifier.urihttps://hdl.handle.net/10468/6252
dc.identifier.volume15en
dc.language.isoenen
dc.publisherAmerican Chemical Society (ACS)en
dc.rights© 2014 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/cg501009cen
dc.subjectFunctional groupsen
dc.subjectFunctional materialsen
dc.subjectSupramolecular chemistryen
dc.subjectActive pharmaceutical ingredientsen
dc.subjectCocrystallizationen
dc.subjectControlled assemblyen
dc.subjectMulticomponent materialsen
dc.subjectPharmacological profilesen
dc.subjectPhysicochemical propertyen
dc.subjectSupramolecular featuresen
dc.subjectSupramolecular synthonsen
dc.titleCocrystallization of nutraceuticalsen
dc.typeArticle (peer-reviewed)en
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