Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype
dc.contributor.author | Dennison, Una | |
dc.contributor.author | McKernan, Declan P. | |
dc.contributor.author | Cryan, John F. | |
dc.contributor.author | Dinan, Timothy G. | |
dc.contributor.funder | Science Foundation Ireland | en |
dc.contributor.funder | GlaxoSmithKline, United Kingdom | en |
dc.date.accessioned | 2013-02-27T17:51:17Z | |
dc.date.available | 2013-02-27T17:51:17Z | |
dc.date.copyright | 2012 | |
dc.date.issued | 2012 | |
dc.description.abstract | Background. Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. Method. We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1b, IL-6, IL-8 and tumour necrosis factor (TNF)-a. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls. Results. Patients with childhood trauma had higher levels of IL-6 and TNF-a than patients without trauma and healthy controls, and TNF-a levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls. Conclusions. Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype. | en |
dc.description.sponsorship | Science Foundation Ireland (SFI-CSET); Science Foundation Ireland and GlaxoSmithKline, United Kingdom (07/CE/B1368) | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | U. Dennison, D. McKernan, J. Cryan and T. Dinan (2012). Schizophrenia patients with a history of childhood trauma have a proinflammatory phenotype. Psychological Medicine, 42(9), pp 1865-1871 doi:10.1017/S0033291712000074 | en |
dc.identifier.doi | 10.1017/S0033291712000074 | |
dc.identifier.endpage | 1871 | en |
dc.identifier.issued | 9 | en |
dc.identifier.journaltitle | Psychological Medicine | en |
dc.identifier.startpage | 1865 | en |
dc.identifier.uri | https://hdl.handle.net/10468/1000 | |
dc.identifier.volume | 42 | en |
dc.language.iso | en | en |
dc.publisher | Cambridge University Press | en |
dc.relation.uri | http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8656043&fulltextType=RA&fileId=S0033291712000074 | |
dc.rights | © Cambridge University Press, 2012 | en |
dc.subject | Schizophrenia | en |
dc.subject | Childhood trauma | en |
dc.subject | Pro-inflammatory Phenotype | en |
dc.subject | ELISA techniques | en |
dc.subject | Interleukin | en |
dc.subject | Tumour necrosis Factor | en |
dc.subject | Inflammation | en |
dc.title | Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype | en |
dc.type | Article (peer-reviewed) | en |