Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype

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dc.contributor.authorDennison, Una
dc.contributor.authorMcKernan, Declan P.
dc.contributor.authorCryan, John F.
dc.contributor.authorDinan, Timothy G.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderGlaxoSmithKline, United Kingdomen
dc.date.accessioned2013-02-27T17:51:17Z
dc.date.available2013-02-27T17:51:17Z
dc.date.copyright2012
dc.date.issued2012
dc.description.abstractBackground. Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. Method. We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1b, IL-6, IL-8 and tumour necrosis factor (TNF)-a. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls. Results. Patients with childhood trauma had higher levels of IL-6 and TNF-a than patients without trauma and healthy controls, and TNF-a levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls. Conclusions. Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype.en
dc.description.sponsorshipScience Foundation Ireland (SFI-CSET); Science Foundation Ireland and GlaxoSmithKline, United Kingdom (07/CE/B1368)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationU. Dennison, D. McKernan, J. Cryan and T. Dinan (2012). Schizophrenia patients with a history of childhood trauma have a proinflammatory phenotype. Psychological Medicine, 42(9), pp 1865-1871 doi:10.1017/S0033291712000074en
dc.identifier.doi10.1017/S0033291712000074
dc.identifier.endpage1871en
dc.identifier.issued9en
dc.identifier.journaltitlePsychological Medicineen
dc.identifier.startpage1865en
dc.identifier.urihttps://hdl.handle.net/10468/1000
dc.identifier.volume42en
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.relation.urihttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8656043&fulltextType=RA&fileId=S0033291712000074
dc.rights© Cambridge University Press, 2012en
dc.subjectSchizophreniaen
dc.subjectChildhood traumaen
dc.subjectPro-inflammatory Phenotypeen
dc.subjectELISA techniquesen
dc.subjectInterleukinen
dc.subjectTumour necrosis Factoren
dc.subjectInflammationen
dc.titleSchizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotypeen
dc.typeArticle (peer-reviewed)en
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