Association between preeclampsia and attention deficit hyperactivity disorder: a population-based and sibling-matched cohort study

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dc.contributor.authorMaher, Gillian M.
dc.contributor.authorDalman, Christina
dc.contributor.authorO'Keeffe, Gerard W.
dc.contributor.authorKearney, Patricia M.
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorKhashan, Ali S.
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2020-02-24T16:29:40Z
dc.date.available2020-02-24T16:29:40Z
dc.date.issued2020-02-13
dc.date.updated2020-02-24T16:16:00Z
dc.description.abstractObjective: Examine the association between preeclampsia and attention deficit hyperactivity disorder (ADHD), using a large Swedish‐based registry cohort. Methods: This study comprised 2,047,619 children, with 114,934 (5.6%) cases of ADHD. Preeclampsia was based on two alternate definitions: 1. Preeclampsia (using ICD‐9/ICD‐10) 2.Preeclampsia and small for gestational age (SGA) combined. ADHD was determined in one of two ways: 1. If a diagnosis of ADHD was present in the National Patient Register or 2.If an individual was in receipt of ADHD medication in the Prescribed Drug Register. Multivariate Cox proportional hazards regression analysis allowed adjustment for several perinatal/sociodemographic factors. Sibling‐matched analysis further controlled for shared genetic and familial confounding. Results: In the adjusted Cox model, preeclampsia was associated with an increase in likelihood of ADHD (HR: 1.15, 95% CI: 1.12, 1.19). The HR for preeclampsia and those born SGA was 1.43 (95% CI: 1.31, 1.55) in the adjusted model, compared to those unexposed to preeclampsia/SGA. The sibling‐matched analysis did not materially change these associations (HR: 1.13, 95% CI: 1.05, 1.22) and 1.55 (95% CI: 1.28, 1.88). Conclusions: Exposure to preeclampsia or preeclampsia/SGA was associated with ADHD, independent of genetic/familial factors shared by siblings. However, it is important to note that sibling‐matched analysis can only adjust for factors that are constant between pregnancies, therefore residual confounding cannot be ruled out. Further research is needed to explore modifiable risk factors and identify those most‐at‐risk babies following delivery.en
dc.description.sponsorshipSPHeRE Programme (grant number SPHeRE/2013/1)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMaher, G. M., Dalman, C., O'Keeffe, G. W., Kearney, P. M., McCarthy, F. P., Kenny, L. C. and Khashan, A. S. 'Association between Preeclampsia and Attention Deficit Hyperactivity Disorder: A Population-Based and Sibling-Matched Cohort Study', Acta Psychiatrica Scandinavica, doi: 10.1111/acps.13162en
dc.identifier.doi10.1111/acps.13162en
dc.identifier.endpage22en
dc.identifier.issn0001-690X
dc.identifier.journaltitleActa Psychiatrica Scandinavicaen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9694
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/acps.13162
dc.rights© 2019 John Wiley & Sons. This is the peer reviewed Accepted Author Manuscript version of the article to be published in final form at https://doi.org/10.1111/acps.13162. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectPreeclampsiaen
dc.subjectObstetric complicationsen
dc.subjectAttention Deficit Hyperactivity Disorderen
dc.subjectEpidemiologyen
dc.subjectADHDen
dc.titleAssociation between preeclampsia and attention deficit hyperactivity disorder: a population-based and sibling-matched cohort studyen
dc.typeArticle (peer-reviewed)en
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