Neuroimmune cross talk in the gut. Neuroendocrine and neuroimmune pathways contribute to the pathophysiology of irritable bowel syndrome

dc.contributor.authorO'Malley, Dervla
dc.contributor.funderWellcome Trusten
dc.contributor.funderUniversity College Corken
dc.date.accessioned2017-01-25T16:21:59Z
dc.date.available2017-01-25T16:21:59Z
dc.date.issued2016-11-09
dc.date.updated2017-01-25T16:15:22Z
dc.description.abstractIrritable bowel syndrome (IBS) is a common disorder characterized by recurrent abdominal pain, bloating, and disturbed bowel habit, symptoms that impact the quality of life of sufferers. The pathophysiological changes underlying this multifactorial condition are complex and include increased sensitivity to luminal and mucosal factors, resulting in altered colonic transit and visceral pain. Moreover, dysfunctional communication in the bidirectional signaling axis between the brain and the gut, which involves efferent and afferent branches of the peripheral nervous system, circulating endocrine hormones, and local paracrine and neurocrine factors, including immune and perhaps even microbial signaling molecules, has a role to play in this disorder. This minireview will examine recent advances in our understanding of the pathophysiology of IBS and assess how cross talk between hormones, immune, and microbe-derived factors and their neuromodulatory effects on peripheral nerves may underlie IBS symptomatology.en
dc.description.sponsorshipWellcome Trust (Seed Award); University College Cork (School of Medicine TRAP funding)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Malley, D. (2016) 'Neuroimmune Cross Talk in the Gut. Neuroendocrine and neuroimmune pathways contribute to the pathophysiology of irritable bowel syndrome', American Journal of Physiology - Gastrointestinal and Liver Physiology, 311(5), pp. G934-G941. doi:10.1152/ajpgi.00272.2016en
dc.identifier.doi10.1152/ajpgi.00272.2016
dc.identifier.endpageG941en
dc.identifier.issn0193-1857
dc.identifier.issued5en
dc.identifier.journaltitleAmerican Journal of Physiology - Gastrointestinal and Liver Physiologyen
dc.identifier.startpageG934en
dc.identifier.urihttps://hdl.handle.net/10468/3522
dc.identifier.volume311en
dc.language.isoenen
dc.publisherAmerican Physiological Societyen
dc.rights© 2016 the American Physiological Societyen
dc.subjectInterleukinsen
dc.subjectGLP-1en
dc.subjectLeptinen
dc.subjectMyentericen
dc.subjectSubmucosalen
dc.titleNeuroimmune cross talk in the gut. Neuroendocrine and neuroimmune pathways contribute to the pathophysiology of irritable bowel syndromeen
dc.typeArticle (peer-reviewed)en
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