Placental ageing in adverse pregnancy outcomes: Telomere shortening, cell senescence, and mitochondrial dysfunction

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dc.contributor.authorManna, Samprikta
dc.contributor.authorMcCarthy, Cathal
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.funderHorizon 2020en
dc.date.accessioned2019-11-20T05:26:38Z
dc.date.available2019-11-20T05:26:38Z
dc.date.issued2019-05-22
dc.description.abstractPreeclampsia is a multisystemic pregnancy disorder and a major cause of maternal and neonatal morbidity and mortality worldwide. The exact pathophysiology of preeclampsia remains unclear; however, it is speculated that the various pathologies can be attributed to impaired vascular remodelling and elevated oxidative stress within the placenta. Oxidative stress plays a key role in cell ageing, and the persistent presence of elevated oxidative stress precipitates cellular senescence and mitochondrial dysfunction, resulting in premature ageing of the placenta. Premature ageing of the placenta is associated with placental insufficiency, which reduces the functional capacity of this critical organ and leads to abnormal pregnancy outcomes. The changes brought about by oxidative insults are irreversible and often lead to deleterious modifications in macromolecules such as lipids and proteins, DNA mutations, and alteration of mitochondrial functioning and dynamics. In this review, we have summarized the current knowledge of placental ageing in the aetiology of adverse pregnancy outcomes and discussed the hallmarks of ageing which could be potential markers for preeclampsia and fetal growth restriction.en
dc.description.sponsorshipMarie Skłodowska-Curie Actions Innovative Training Networken
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid3095383en
dc.identifier.citationManna, S., McCarthy, C. and McCarthy, F.P., 2019. Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction. Oxidative Medicine and Cellular Longevity, 2019. (11pp). DOI:10.1155/2019/3095383en
dc.identifier.doi10.1155/2019/3095383en
dc.identifier.eissn1942-0994
dc.identifier.endpage12en
dc.identifier.issn1942-0900
dc.identifier.journaltitleOxidative Medicine and Cellular Longevityen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9127
dc.identifier.volume2019en
dc.language.isoenen
dc.publisherHindawien
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-ITN-ETN/765274/EU/Innovation in modelling Placenta for Maternal and Fetal Health/iPLACENTAen
dc.relation.urihttps://www.hindawi.com/journals/omcl/2019/3095383/
dc.rights© 2019 Samprikta Manna et alen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPreeclampsiaen
dc.subjectNeonatal morbidityen
dc.subjectNeonatal mortalityen
dc.subjectPlacental ageingen
dc.titlePlacental ageing in adverse pregnancy outcomes: Telomere shortening, cell senescence, and mitochondrial dysfunctionen
dc.typeArticle (peer-reviewed)en
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