Nano in micro: novel concepts in foodborne pathogen transmission and pathogenesis

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dc.contributor.authorLiu, Yueen
dc.contributor.authorMa, Xuchuanen
dc.contributor.authorCazzaniga, Monicaen
dc.contributor.authorGahan, Cormac G. M.en
dc.contributor.authorden Besten, Heidy M. W.en
dc.contributor.authorAbee, Tjakkoen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020en
dc.date.accessioned2025-04-28T09:08:37Z
dc.date.available2025-04-28T09:08:37Z
dc.date.issued2024-12-02en
dc.description.abstractIn this article, we highlight novel components of foodborne pathogens that influence their response, physiology, adaptation, and survival in the face of diverse stresses, and consequently have implications for their transmission in the food chain and their pathogenesis. Recent insights into the role of bacteriophages/prophages, bacterial extracellular vesicles, and bacterial microcompartments, which make up the emerging field we coined as “nano in micro,” are presented, together with the role of understudied food-relevant substrates in pathogen fitness and virulence. These new insights also lead to reflections on generally adopted laboratory conditions in the long-standing research field of adaptive stress response in foodborne pathogens. In addition, selected examples of the impact of diet and microbiota on intestinal colonization and host invasion are discussed. A final section on risk assessment presents an overview of tools for (kinetic) data modeling and perspectives for the implementation of information derived from whole-genome sequencing, combined with advancements in dose-response models and exposure assessments.en
dc.description.sponsorshipScience Foundation Ireland (grant number SFI/12/RC/2273_P2); Horizon 2020 (956279)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2en
dc.identifier.citationLiu, Y., Ma, X., Cazzaniga, M., Gahan, C. G., den Besten, H. M. and Abee, T. (2024) 'Nano in micro: novel concepts in foodborne pathogen transmission and pathogenesis', Annual Review of Food Science and Technology, 12(1), 2 (24pp). https://doi.org/10.1146/annurev-food-111523-121811en
dc.identifier.doi10.1146/annurev-food-111523-121811en
dc.identifier.eissn1941-1421en
dc.identifier.endpage24en
dc.identifier.issn1941-1413en
dc.identifier.issued1en
dc.identifier.journaltitleAnnual Review of Food Science and Technologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/17350
dc.identifier.volume12en
dc.language.isoenen
dc.publisherAnnual Reviewsen
dc.relation.ispartofAnnual Review of Food Science and Technologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Research Centres Programme::Phase 2/12/RC/2273_P2/IE/APC_Phase 2/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-ITN-ETN/956279/EU/Colonization resistance: training and research towards microbiome derived solutions to foodborne disease/COL_RESen
dc.rights© 2025, the authors.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBacteriophageen
dc.subjectExtracellular vesicleen
dc.subjectBacterial microcompartmenten
dc.subjectCarbon sourceen
dc.subjectPathogen–microbiota–host interactionsen
dc.subjectRisk assessmenten
dc.titleNano in micro: novel concepts in foodborne pathogen transmission and pathogenesisen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
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