The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems

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dc.contributor.authorFlandroy, Lucette
dc.contributor.authorPoutahidis, Theofilos
dc.contributor.authorBerg, Gabriele
dc.contributor.authorClarke, Gerard
dc.contributor.authorDao, Maria-Carlota
dc.contributor.authorDecaestecker, Ellen
dc.contributor.authorFurman, Eeva
dc.contributor.authorHaahtela, Tari
dc.contributor.authorMassart, Sébastien
dc.contributor.authorPlovier, Hubert
dc.contributor.authorSanz, Yolanda
dc.contributor.authorRook, Graham
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderFonds Wetenschappelijk Onderzoek
dc.contributor.funderSeventh Framework Programme
dc.contributor.funderAustrian Science Fund
dc.contributor.funderHorizon 2020 Framework Programme
dc.contributor.funderAssistance Publique - Hôpitaux de Paris
dc.contributor.funderFonds De La Recherche Scientifique - FNRS
dc.date.accessioned2018-03-09T12:55:06Z
dc.date.available2018-03-09T12:55:06Z
dc.date.issued2018
dc.description.abstractPlants, animals and humans, are colonized by microorganisms (microbiota) and transiently exposed to countless others. The microbiota affects the development and function of essentially all organ systems, and contributes to adaptation and evolution, while protecting against pathogenic microorganisms and toxins. Genetics and lifestyle factors, including diet, antibiotics and other drugs, and exposure to the natural environment, affect the composition of the microbiota, which influences host health through modulation of interrelated physiological systems. These include immune system development and regulation, metabolic and endocrine pathways, brain function and epigenetic modification of the genome. Importantly, parental microbiotas have transgenerational impacts on the health of progeny. Humans, animals and plants share similar relationships with microbes. Research paradigms from humans and other mammals, amphibians, insects, planktonic crustaceans and plants demonstrate the influence of environmental microbial ecosystems on the microbiota and health of organisms, and indicate links between environmental and internal microbial diversity and good health. Therefore, overlapping compositions, and interconnected roles of microbes in human, animal and plant health should be considered within the broader context of terrestrial and aquatic microbial ecosystems that are challenged by the human lifestyle and by agricultural and industrial activities. Here, we propose research priorities and organizational, educational and administrative measures that will help to identify safe microbe-associated health-promoting modalities and practices. In the spirit of an expanding version of “One health” that includes environmental health and its relation to human cultures and habits (EcoHealth), we urge that the lifestyle-microbiota-human health nexus be taken into account in societal decision making.en
dc.description.sponsorshipFonds Wetenschappelijk Onderzoek (grant G.0643.13); Austrian Science Fund (FWF; P29285-BBL)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationFlandroy, L., Poutahidis, T., Berg, G., Clarke, G., Dao, M.-C., Decaestecker, E., Furman, E., Haahtela, T., Massart, S., Plovier, H., Sanz, Y. and Rook, G. (2018) 'The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems', Science of the Total Environment, 627, pp. 1018-1038. doi: 10.1016/j.scitotenv.2018.01.288en
dc.identifier.doi10.1016/j.scitotenv.2018.01.288
dc.identifier.endpage1038
dc.identifier.issn0048-9697
dc.identifier.issn1879-1026
dc.identifier.journaltitleScience of the Total Environmenten
dc.identifier.startpage1018
dc.identifier.urihttps://hdl.handle.net/10468/5602
dc.identifier.volume627
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/612713/EU/Biological control manufacturers in Europe develop novel biological control products to support the implementation of Integrated Pest Management in agriculture and forestry/BIOCOMES
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/305312/EU/Metagenomics in Cardiometabolic Diseases/METACARDIS
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/634413/EU/Elucidating Pathways of Steatohepatitis/EPoS
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0048969718303413
dc.rights© 2018, the Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMicrobesen
dc.subjectNatural environmenten
dc.subjectHealthen
dc.subjectImmunoregulationen
dc.subjectBiodiversityen
dc.subjectSoilen
dc.titleThe impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystemsen
dc.typeArticle (peer-reviewed)en
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