Strain differences in behaviour and immunity in aged mice: Relevance to autism.

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dc.contributor.authorO'Connor, Rory
dc.contributor.authorvan de Wouw, Marcel
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorVentura-Silva, Ana Paula
dc.contributor.authorO'Riordan, Ken
dc.contributor.authorGolubeva, Anna V.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorSchellekens, Harriët
dc.contributor.authorCryan, John F.
dc.date.accessioned2020-11-25T12:31:45Z
dc.date.available2020-11-25T12:31:45Z
dc.date.issued2020-11-20
dc.date.updated2020-11-25T12:17:57Z
dc.description.abstractThe BTBR mouse model has been shown to be associated with deficits social interaction and a pronounced engagement in repetitive behaviours. Autism spectrum disorder (ASD) is the most prevalent neurodevelopmental condition globally. Despite its ubiquity, most research into the disorder remains focused on childhood, with studies in adulthood and old age relatively rare. To this end, we explored the differences in behaviour and immune function in an aged BTBR T + Itpr3tf/J mouse model of the disease compared to a similarly aged C57bl/6 control. We show that while many of the alterations in behaviour that are observed in young animals are maintained (repetitive behaviours, antidepressant-sensitive behaviours, social deficits & cognition) there are more nuanced effects in terms of anxiety in older animals of the BTBR strain compared to C57bl/6 controls. Furthermore, BTBR animals also exhibit an activated T-cell system. As such, these results represent confirmation that ASD-associated behavioural deficits are maintained in ageing, and that that there may be need for differential interventional approaches to counter these impairments, potentially through targeting the immune system.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid113020en
dc.identifier.citationO’Connor, R., van De Wouw, M., Moloney, G. M., Ventura-Silva, A. P., O’Riordan, K., Golubeva, A. V., Dinan, T. G., Schellekens, H. and Cryan, J. F. (2021) 'Strain differences in behaviour and immunity in aged mice: Relevance to Autism', Behavioural Brain Research, 399, 113020 (10 pp). doi: 10.1016/j.bbr.2020.113020en
dc.identifier.doi10.1016/j.bbr.2020.113020en
dc.identifier.issn1872-7549
dc.identifier.issn0166-4328
dc.identifier.journaltitleBehavioural Brain Researchen
dc.identifier.urihttps://hdl.handle.net/10468/10787
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rights© 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAutismen
dc.subjectFlow-Cytometryen
dc.subjectBTBRen
dc.subjectAgeingen
dc.titleStrain differences in behaviour and immunity in aged mice: Relevance to autism.en
dc.typeArticle (peer-reviewed)en
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