Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe

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dc.contributor.authorRyan, Paul M.
dc.contributor.authorStolte, Ellen H.
dc.contributor.authorLondon, Lis E. E.
dc.contributor.authorWells, Jerry M.
dc.contributor.authorLong, Sarah L.
dc.contributor.authorJoyce, Susan A.
dc.contributor.authorGahan, Cormac G. M.
dc.contributor.authorFitzgerald, Gerald F.
dc.contributor.authorRoss, R. Paul
dc.contributor.authorCaplice, Noel M.
dc.contributor.authorStanton, Catherine
dc.contributor.funderTeagascen
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-11-26T05:59:28Z
dc.date.available2019-11-26T05:59:28Z
dc.date.issued2019-02-08
dc.description.abstractLactobacillus mucosae DPC 6426 has previously demonstrated potentially cardio-protective properties, in the form of dyslipidaemia and hypercholesterolemia correction in an apolipoprotein-E deficient mouse model. This study aims to characterise the manner in which this microbe may modulate host bile pool composition and immune response, in the context of cardiovascular disease. Lactobacillus mucosae DPC 6426 was assessed for bile salt hydrolase activity and specificity. The microbe was compared against several other enteric strains of the same species, as well as a confirmed bile salt hydrolase-active strain, Lactobacillus reuteri APC 2587.en
dc.description.sponsorshipEnterprise Ireland Commercialisation Fund (grant number CF/2013/3030A/B); Teagasc (Walsh Fellowship Scheme)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid33en
dc.identifier.citationRyan, P.M., Stolte, E.H., London, L.E., Wells, J.M., Long, S.L., Joyce, S.A., Gahan, C.G., Fitzgerald, G.F., Ross, R.P., Caplice, N.M. and Stanton, C. (2019) 'Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe'. BMC microbiology, 19(1), 33. (13 pp.). DOI:10.1186/s12866-019-1403-0en
dc.identifier.doi10.1186/s12866-019-1403-0en
dc.identifier.eissn1471-2180
dc.identifier.endpage13en
dc.identifier.issued1en
dc.identifier.journaltitleBMC Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9237
dc.identifier.volume19en
dc.language.isoenen
dc.publisherBMC part of Springer Natureen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/289517/EU/Dietary Fibers supporting Gut and Immune Function - From polysaccharide compound to health claim/FIBEBIOTICSen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-019-1403-0
dc.rights© The Author(s). 2019en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectExopolysaccharideen
dc.subjectBile aciden
dc.subjectBile salt hydrolase (BSH)en
dc.subjectHypercholesterolaemiaen
dc.subjectCVDen
dc.titleLactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbeen
dc.typeArticle (peer-reviewed)en
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