Hypertensive disorders of pregnancy and behavioural outcomes in the offspring: Findings from the Millennium Cohort Study

Maher, Gillian M.; McCarthy, Fergus P.; Khashan, Ali S.

Hypertensive disorders of pregnancy and behavioural outcomes in the offspring: Findings from the Millennium Cohort Study

dc.check.date	2022-03-19
dc.check.info	Access to this article is restricted until 12 months after publication by request of the publisher.	en
dc.contributor.author	Maher, Gillian M.
dc.contributor.author	McCarthy, Fergus P.
dc.contributor.author	Khashan, Ali S.
dc.contributor.funder	Health Research Board	en
dc.date.accessioned	2021-05-26T09:12:51Z
dc.date.available	2021-05-26T09:12:51Z
dc.date.issued	2021-03-19
dc.date.updated	2021-05-26T09:02:25Z
dc.description.abstract	Background: The aim of this study was to examine the association between hypertensive disorders of pregnancy (HDP) and behavioural outcomes in offspring at five time-points. Methods: We used maternal-reported data from the Millennium Cohort Study. Data on HDP were collected when children were 9-months. Data on behavioural outcomes were collected at age 3, 5, 7, 11 and 14years using the Strengths and Difficulties Questionnaire (SDQ). Multivariate logistic regression analysis examined a HDP-behavioural difficulties relationship, using validated SDQ cut-off points. Multilevel models with linear splines examined the association between HDP and repeated measures of SDQ. Results: 18,274 singleton children were included in the study at baseline, Multivariate logistic regression suggested HDP was not significantly associated with SDQ domain cut-off points at ages 3, 7 and 11years. At age 5years, HDP was associated with a 40% increased odds of behavioural difficulties based on total SDQ(≥17) (OR:1.40, 95% CI:1.03,1.91). HDP was associated with a 43% increased odds of Peer Problem difficulties at age 5 (OR:1.43, 95% CI:1.10,1.86), and a 28% increased odds of Peer Problem difficulties(≥4) at age 14 (OR:1.28, 95% CI:1.02,1.61). In the linear spline model, mean SDQ score was higher at each time-point in those exposed to HDP, although did not always reach statistical significance. Limitations: Data on different classifications of HDP were unavailable; therefore, we could not examine the effect of gestational hypertension and preeclampsia separately. Conclusions: While we did not find strong evidence of associations between HDP and behavioural outcomes overall, some associations between HDP and behavioural difficulties did persist at age 5 and 14years.	en
dc.description.sponsorship	Health Research Board (Grant number SDAP2019/6359)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Maher, G. M., McCarthy, F. P. and Khashan, A. S. (2021) 'Hypertensive disorders of pregnancy and behavioural outcomes in the offspring: Findings from the Millennium Cohort Study', Journal of Affective Disorders, 287, pp.222-228. doi: 10.1016/j.jad.2021.03.040	en
dc.identifier.doi	10.1016/j.jad.2021.03.040	en
dc.identifier.endpage	228	en
dc.identifier.issn	1573-2517
dc.identifier.issn	0165-0327
dc.identifier.journaltitle	Journal of Affective Disorders	en
dc.identifier.startpage	222	en
dc.identifier.uri	https://hdl.handle.net/10468/11388
dc.identifier.volume	287	en
dc.language.iso	en	en
dc.publisher	Elsevier B.V.	en
dc.rights	© 2021, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.subject	Hypertensive disorders of pregnancy	en
dc.subject	Behavioural outcomes	en
dc.subject	Epidemiology	en
dc.subject	Millennium Cohort Study	en
dc.title	Hypertensive disorders of pregnancy and behavioural outcomes in the offspring: Findings from the Millennium Cohort Study	en
dc.type	Article (peer-reviewed)	en