Hypertensive disorders of pregnancy and behavioural outcomes in the offspring: Findings from the Millennium Cohort Study

dc.check.date2022-03-19
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorMaher, Gillian M.
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorKhashan, Ali S.
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2021-05-26T09:12:51Z
dc.date.available2021-05-26T09:12:51Z
dc.date.issued2021-03-19
dc.date.updated2021-05-26T09:02:25Z
dc.description.abstractBackground: The aim of this study was to examine the association between hypertensive disorders of pregnancy (HDP) and behavioural outcomes in offspring at five time-points. Methods: We used maternal-reported data from the Millennium Cohort Study. Data on HDP were collected when children were 9-months. Data on behavioural outcomes were collected at age 3, 5, 7, 11 and 14years using the Strengths and Difficulties Questionnaire (SDQ). Multivariate logistic regression analysis examined a HDP-behavioural difficulties relationship, using validated SDQ cut-off points. Multilevel models with linear splines examined the association between HDP and repeated measures of SDQ. Results: 18,274 singleton children were included in the study at baseline, Multivariate logistic regression suggested HDP was not significantly associated with SDQ domain cut-off points at ages 3, 7 and 11years. At age 5years, HDP was associated with a 40% increased odds of behavioural difficulties based on total SDQ(≥17) (OR:1.40, 95% CI:1.03,1.91). HDP was associated with a 43% increased odds of Peer Problem difficulties at age 5 (OR:1.43, 95% CI:1.10,1.86), and a 28% increased odds of Peer Problem difficulties(≥4) at age 14 (OR:1.28, 95% CI:1.02,1.61). In the linear spline model, mean SDQ score was higher at each time-point in those exposed to HDP, although did not always reach statistical significance. Limitations: Data on different classifications of HDP were unavailable; therefore, we could not examine the effect of gestational hypertension and preeclampsia separately. Conclusions: While we did not find strong evidence of associations between HDP and behavioural outcomes overall, some associations between HDP and behavioural difficulties did persist at age 5 and 14years.en
dc.description.sponsorshipHealth Research Board (Grant number SDAP2019/6359)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMaher, G. M., McCarthy, F. P. and Khashan, A. S. (2021) 'Hypertensive disorders of pregnancy and behavioural outcomes in the offspring: Findings from the Millennium Cohort Study', Journal of Affective Disorders, 287, pp.222-228. doi: 10.1016/j.jad.2021.03.040en
dc.identifier.doi10.1016/j.jad.2021.03.040en
dc.identifier.endpage228en
dc.identifier.issn1573-2517
dc.identifier.issn0165-0327
dc.identifier.journaltitleJournal of Affective Disordersen
dc.identifier.startpage222en
dc.identifier.urihttps://hdl.handle.net/10468/11388
dc.identifier.volume287en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rights© 2021, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectHypertensive disorders of pregnancyen
dc.subjectBehavioural outcomesen
dc.subjectEpidemiologyen
dc.subjectMillennium Cohort Studyen
dc.titleHypertensive disorders of pregnancy and behavioural outcomes in the offspring: Findings from the Millennium Cohort Studyen
dc.typeArticle (peer-reviewed)en
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