Vitamin D in pregnancy: current perspectives and future directions

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dc.contributor.authorKiely, Mairead E.
dc.contributor.authorHemmingway, Andrea
dc.contributor.authorO'Callaghan, Karen M.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSeventh Framework Programmeen
dc.date.accessioned2019-08-02T08:34:11Z
dc.date.available2019-08-02T08:34:11Z
dc.date.issued2017-05-02
dc.date.updated2019-08-01T11:55:01Z
dc.description.abstractAs neonatal vitamin D status is determined by circulating maternal 25-hydroxyvitamin D [25(OH)D] concentrations, prevention of maternal vitamin D deficiency during pregnancy is essential for the avoidance of neonatal deficiency. However, a high prevalence of vitamin D deficiency has been extensively reported among gravidae and neonates from ethnic minorities and white populations resident at high latitude. Currently, regulatory authorities recommend vitamin D intakes for pregnant women that are similar to non-pregnant adults of the same age, at 10–15 µg/day (400–600 IU), to meet 25(OH)D thresholds of 25–50 nmol/liter. The lack of pregnancy-specific dietary recommendations is due to inadequate data indicating whether nutritional requirements for vitamin D during pregnancy differ from the non-pregnant state. In addition, there are few dose–response studies to determine the maternal 25(OH)D response to vitamin D intake throughout pregnancy at high latitude. These data are also required to determine vitamin D requirements during pregnancy for prevention of neonatal deficiency, an outcome which is likely to require a higher maternal 25(OH)D concentration than prevention of maternal deficiency only. With regard to the impact of vitamin D on perinatal health outcomes, which could guide pregnancy-specific 25(OH)D thresholds, dietary intervention studies to date have been inconsistent and recent systematic reviews have highlighted issues of low quality and a high risk of bias as drawbacks in the trial evidence to date. Many observational studies have been hampered by a reliance on retrospective data, unclear reporting, suboptimal clinical phenotyping and incomplete subject characterization. Current investigations of vitamin D metabolism during pregnancy have potentially exciting implications for clinical research. This paper provides an update of current dietary recommendations for vitamin D in pregnant women and a synopsis of the evidence relating vitamin D status with maternal and infant health.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKiely, M., Hemmingway, A. and O'Callaghan, K. M. (2017) 'Vitamin D in pregnancy: current perspectives and future directions', Therapeutic Advances in Musculoskeletal Disease, 9(6), pp. 145-154. doi: 10.1177/1759720x17706453en
dc.identifier.doi10.1177/1759720x17706453en
dc.identifier.endpage154en
dc.identifier.issn1759-720X
dc.identifier.issn1759-7218
dc.identifier.issued6en
dc.identifier.journaltitleTherapeutic Advances in Musculoskeletal Diseaseen
dc.identifier.startpage145en
dc.identifier.urihttps://hdl.handle.net/10468/8281
dc.identifier.volume9en
dc.language.isoenen
dc.publisherSAGE Publicationsen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Spokes Programme/14/SP APC INFANT/B3067/IE/The Cork Nutrition and Microbiome Maternal-Infant Cohort Study (COMBINE)/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODINen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://journals.sagepub.com/doi/abs/10.1177/1759720X17706453
dc.rights© 2017, the Authors. Published by SAGE publications. All rights reserved.en
dc.subjectVitamin D and pregnant womenen
dc.subjectVitamin D requirementsen
dc.subjectNeonatal vitamin D statusen
dc.titleVitamin D in pregnancy: current perspectives and future directionsen
dc.typeArticle (peer-reviewed)en
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