Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients

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dc.contributor.authorHamilton, Hilary J.
dc.contributor.authorGallagher, Paul F.
dc.contributor.authorRyan, Cristin
dc.contributor.authorByrne, Stephen
dc.contributor.authorO'Mahony, Denis
dc.contributor.funderHealth Research Boarden
dc.contributor.funderEnterprise Irelanden
dc.date.accessioned2017-04-10T09:25:02Z
dc.date.available2017-04-10T09:25:02Z
dc.date.issued2011-06
dc.date.updated2017-04-10T09:18:54Z
dc.description.abstractBackground: Previous studies have not demonstrated a consistent association between potentially inappropriate medicines (PIMs) in older patients as defined by Beers criteria and avoidable adverse drug events (ADEs). This study aimed to assess whether PIMs defined by new STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) criteria are significantly associated with ADEs in older people with acute illness. Methods: We prospectively studied 600 consecutive patients 65 years or older who were admitted with acute illness to a university teaching hospital over a 4-month interval. Potentially inappropriate medicines were defined by both Beers and STOPP criteria. Adverse drug events were defined by World Health Organization- Uppsala Monitoring Centre criteria and verified by a local expert consensus panel, which also assessed whether ADEs were causal or contributory to current hospitalization. Hallas criteria defined ADE avoidability. We compared the proportions of patients taking Beers criteria PIMs and STOPP criteria PIMs with avoidable ADEs that were causal or contributory to admission. Results: A total of 329 ADEs were detected in 158 of 600 patients (26.3%); 219 of 329 ADEs (66.6%) were considered causal or contributory to admission. Of the 219 ADEs, 151(68.9%) considered causal or contributory to admission were avoidable or potentially avoidable. After adjusting for age, sex, comorbidity, dementia, baseline activities of daily living function, and number of medications, the likelihood of a serious avoidable ADE increased significantly when STOPP PIMs were prescribed (odds ratio, 1.847; 95% confidence interval [CI], 1.506-2.264;P<.001);prescription of Beers criteria PIMs did not significantly increase ADE risk (odds ratio, 1.276; 95% CI, 0.945-1.722; P=.11). Conclusion: STOPP criteria PIMs, unlike Beers criteria PIMs, are significantly associated with avoidable ADEs in older people that cause or contribute to urgent hospitalization.en
dc.description.sponsorshipHealth Research Board (research fellowship); Enterprise Ireland (research funding)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHamilton, H., Gallagher, P., Ryan, C., Byrne, S. and O’Mahony, D. (2011) 'Potentially inappropriate medications defined by stopp criteria and the risk of adverse drug events in older hospitalized patients', Archives of Internal Medicine, 171(11), pp. 1013-1019. doi:10.1001/archinternmed.2011.215en
dc.identifier.doi10.1001/archinternmed.2011.215
dc.identifier.endpage1019en
dc.identifier.issn0003-9926
dc.identifier.issued11en
dc.identifier.journaltitleArchives of Internal Medicineen
dc.identifier.startpage1013en
dc.identifier.urihttps://hdl.handle.net/10468/3863
dc.identifier.volume171en
dc.language.isoenen
dc.publisherAmerican Medical Association (AMA)en
dc.rights© 2011 American Medical Association. All rights reserveden
dc.subjectAdverse drug reaction reporting systemsen
dc.subjectChi-square distributionen
dc.subjectComorbidityen
dc.subjectDrug toxicityen
dc.subjectInappropriate prescribingen
dc.subjectInpatientsen
dc.subjectIrelanden
dc.subjectMedication errorsen
dc.subjectPharmaceutical preparationsen
dc.subjectPolypharmacyen
dc.subjectRegression analysisen
dc.subjectRisken
dc.subjectBeers criteriaen
dc.titlePotentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patientsen
dc.typeArticle (peer-reviewed)en
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