Microbiota and body weight control: weight watchers within?

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dc.contributor.authorBoscaini, Serena
dc.contributor.authorLeigh, Sarah-Jane
dc.contributor.authorLavelle, Aonghus
dc.contributor.authorGarcía-Cabrerizo, Rubén
dc.contributor.authorLipuma, Timothy
dc.contributor.authorClarke, Gerard
dc.contributor.authorSchellekens, Harriët
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2022-04-05T10:33:51Z
dc.date.available2022-04-05T10:33:51Z
dc.date.issued2022-03
dc.date.updated2022-04-05T10:15:43Z
dc.description.abstractDespite several decades of research, managing body weight remains an unsolved clinical problem. Health problems associated with dysregulated body weight, such as obesity and cachexia, exhibit several gut microbiota alterations. There is an increased interest in utilising the gut microbiota for body weight control, as it responds to intervention and plays an important role in energy extraction from food, as well as biotransformation of nutrients. This review provides an overview of the role of the gut microbiota in the physiological and metabolic alterations observed in two body weight dysregulation-related disorders, namely obesity and cachexia. Second, we assess the available evidence for different strategies, including caloric restriction, intermittent fasting, ketogenic diet, bariatric surgery, probiotics, prebiotics, synbiotics, high-fibre diet, and fermented foods - effects on body weight and gut microbiota composition. This approach was used to give insights into the possible link between body weight control and gut microbiota configuration. Despite extensive associations between body weight and gut microbiota composition, limited success could be achieved in the translation of microbiota-related interventions for body weight control in humans. Manipulation of the gut microbiota alone is insufficient to alter body weight and future research is needed with a combination of strategies to enhance the effects of lifestyle interventions.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid101427en
dc.identifier.citationBoscaini, S., Leigh, S-J., Lavelle, A., García-Cabrerizo, R.; Lipuma, T., Clarke, G., Schellekens, H. and Cryan, J. F. (2022) 'Microbiota and body weight control: weight watchers within?', Molecular Metabolism, 57, 101427 (30 pp). doi: 10.1016/j.molmet.2021.101427en
dc.identifier.doi10.1016/j.molmet.2021.101427en
dc.identifier.endpage30en
dc.identifier.issn2212-8778
dc.identifier.journaltitleMolecular Metabolismen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13031
dc.identifier.volume57en
dc.language.isoenen
dc.publisherElsevier GmbHen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2022 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectBody weighten
dc.subjectObesityen
dc.subjectGut microbiotaen
dc.subjectCachexiaen
dc.subjectDietary interventionen
dc.subjectMetabolismen
dc.titleMicrobiota and body weight control: weight watchers within?en
dc.typeArticle (peer-reviewed)en
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