dc.contributor.author	Fouhy, Fiona
dc.contributor.author	Watkins, Claire
dc.contributor.author	Hill, Cian J.
dc.contributor.author	O'Shea, Carol Anne
dc.contributor.author	Nagle, Brid
dc.contributor.author	Dempsey, Eugene M.
dc.contributor.author	O'Toole, Paul W.
dc.contributor.author	Ross, R. Paul
dc.contributor.author	Ryan, C. Anthony
dc.contributor.author	Stanton, Catherine
dc.contributor.funder	Department of Agriculture, Food and the Marine	en
dc.contributor.funder	Health Research Board	en
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2019-11-19T12:01:20Z
dc.date.available	2019-11-19T12:01:20Z
dc.date.issued	2019-04-03
dc.description.abstract	Perinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae (year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age.	en
dc.description.sponsorship	INFANTMET project	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	1517	en
dc.identifier.citation	Fouhy, F., Watkins, C., Hill, C.J., O’Shea, C.A., Nagle, B., Dempsey, E.M., O’Toole, P.W., Ross, R.P., Ryan, C.A. and Stanton, C., 2019. Perinatal factors affect the gut microbiota up to four years after birth. Nature communications, 10(1), (1517). DOI:10.1038/s41467-019-09252-4	en
dc.identifier.doi	10.1038/s41467-019-09252-4	en
dc.identifier.eissn	2041-1723
dc.identifier.endpage	10	en
dc.identifier.issued	1	en
dc.identifier.journaltitle	Nature Communications	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/9071
dc.identifier.volume	10	en
dc.language.iso	en	en
dc.publisher	Springer Nature	en
dc.relation.uri	https://www.nature.com/articles/s41467-019-09252-4
dc.rights	© The Author(s) 2019	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Gut microbiota	en
dc.subject	Perinatal factors	en
dc.title	Perinatal factors affect the gut microbiota up to four years after birth	en
dc.type	Article (peer-reviewed)	en

Perinatal factors affect the gut microbiota up to four years after birth

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