Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions

dc.contributor.authorRyan, Paul M.
dc.contributor.authorStanton, Catherine
dc.contributor.authorCaplice, Noel M.
dc.contributor.funderEnterprise Ireland
dc.contributor.funderScience Foundation Ireland
dc.description.abstractWhile basic and clinical research over the last several decades has recognized a number of modifiable risk factors associated with cardiometabolic disease progression, additional and alternative biological perspectives may offer novel targets for prevention and treatment of this disease set. There is mounting preclinical and emerging clinical evidence indicating that the mass of metabolically diverse microorganisms which inhabit the human gastrointestinal tract may be implicated in initiation and modulation of cardiovascular and metabolic disease outcomes. The following review will discuss this gut microbiome–host metabolism axis and address newly proposed bile-mediated signaling pathways through which dysregulation of this homeostatic axis may influence host cardiovascular risk. With a central focus on the major nuclear and membrane-bound bile acid receptor ligands, we aim to review the putative impact of microbial bile acid modification on several major phenotypes of metabolic syndrome, from obesity to heart failure. Finally, attempting to synthesize several separate but complementary hypotheses, we will review current directions in preclinical and clinical investigation in this evolving field.en
dc.description.sponsorshipEnterprise Ireland (CF/2013/3030A/B).en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.identifier.citationRyan, P. M., Stanton, C. and Caplice, N. M. (2017) 'Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions', Diabetology and Metabolic Syndrome, 9(1), 102 (12pp). doi: 10.1186/s13098-017-0299-9en
dc.identifier.journaltitleDiabetology and Metabolic Syndromeen
dc.publisherBioMed Centralen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.rights© 2017, the Authors. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en
dc.subjectBile acidsen
dc.subjectCardiovascular diseaseen
dc.subjectMetabolic syndromeen
dc.titleBile acids at the cross-roads of gut microbiome–host cardiometabolic interactionsen
dc.typeArticle (peer-reviewed)en
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