The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months

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dc.contributor.authorHawkes, Colin P.
dc.contributor.authorGrimberg, Adda
dc.contributor.authorKenny, Louise C.
dc.contributor.authorKiely, Mairead E.
dc.contributor.authorHourihane, Jonathan O'B.
dc.contributor.authorIrvine, Alan D.
dc.contributor.authorMcPhaul, Michael J.
dc.contributor.authorCaulfield, Michael P.
dc.contributor.authorZemel, Babette S.
dc.contributor.authorMurray, Deirdre M.
dc.contributor.funderEunice Kennedy Shriver National Institute of Child Health and Human Developmenten
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderNational Children’s Research Centre, Irelanden
dc.date.accessioned2019-04-16T15:39:57Z
dc.date.available2019-04-16T15:39:57Z
dc.date.issued2019-02-11
dc.date.updated2019-04-16T15:21:06Z
dc.description.abstractBackground: Insulin-like growth factor (IGF)-I and -II play an important role in prenatal growth. During the first 2 months from birth, body fat doubles, and rapid weight gain during this time increases future risk of cardiometabolic disease. The aim of this study was to determine whether IGF measurements at birth associate with body composition and the trajectory of its changes in the first 2 months. Methods: Umbilical cord IGF-I and -II concentrations were measured in term infants. Air displacement plethysmography was performed at birth and 2 months. Fat mass (FM) and fat-free mass (FFM) were corrected for infant length (L) to FM/L3 and FFM/L2, respectively. Results: In 601 (317 male) infants, IGF-I concentrations at birth were associated with FM/L3 and FFM/L2 Z-scores at birth (R2 = 0.05 and 0.04, respectively, P < 0.001), and IGF-II concentrations were associated with FFM/L2 Z-scores at birth (R2 = 0.01, P = 0.02). Lower IGF-I concentrations were weakly associated with increases in FM/L3 Z-scores over the first 2 months (R2 = 0.01, P = 0.003). Conclusion: IGF-I concentrations at birth are associated with adiposity and lean mass at birth and inversely with the trajectory of FM accumulation over the first 2 months. IGF-I measurements only account for a small amount of the variance in these measures.en
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD grant 1R01 HD57037); Health Research Board of Ireland (The SCOPE Ireland Study (CSA 02/2007)); National Children’s Research Centre, Ireland ((PhD grant); (Cork BASELINE birth cohort))en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHawkes, C. P., Grimberg, A., Kenny, L. C., Kiely, M., Hourihane, J. O. B., Irvine, A. D., McPhaul, M. J., Caulfield, M. P., Zemel, B. S. and Murray, D. M. (2019) 'The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months', Pediatric Research, 85(5), pp. 687-692. doi: 10.1038/s41390-019-0331-xen
dc.identifier.doi10.1038/s41390-019-0331-xen
dc.identifier.endpage692en
dc.identifier.issn1530-0447
dc.identifier.issued5en
dc.identifier.journaltitlePediatric Researchen
dc.identifier.startpage687en
dc.identifier.urihttps://hdl.handle.net/10468/7772
dc.identifier.volume85en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/08/IN.1/B2083/IE/The development of a metabolic biomarker based screening test to identify uteroplacental insufficiency in pregnancy/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://www.nature.com/articles/s41390-019-0331-x
dc.rights© 2018 the authors. Published by Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in Pediatric Research. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41390-019-0305-zen
dc.subjectCork BASELINE birth cohort.en
dc.subjectSomatomedin Ben
dc.subjectSomatomedin Cen
dc.subjectBody compositionen
dc.subjectClinical trialen
dc.subjectCohort analysisen
dc.subjectFat free massen
dc.subjectFat massen
dc.subjectUmbilical corden
dc.titleThe relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 monthsen
dc.typeArticle (peer-reviewed)en
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