Cross talk: the microbiota and neurodevelopmental disorders

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dc.contributor.authorKelly, John R.
dc.contributor.authorMinuto, Chiara
dc.contributor.authorCryan, John F.
dc.contributor.authorClarke, Gerard
dc.contributor.authorDinan, Timothy G.
dc.contributor.funderBrain and Behavior Research Foundation
dc.contributor.funderSeventh Framework Programme
dc.contributor.funderHealth Research Board
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2017-10-18T09:40:15Z
dc.date.available2017-10-18T09:40:15Z
dc.date.issued2017
dc.description.abstractHumans evolved within a microbial ecosystem resulting in an interlinked physiology. The gut microbiota can signal to the brain via the immune system, the vagus nerve or other host-microbe interactions facilitated by gut hormones, regulation of tryptophan metabolism and microbial metabolites such as short chain fatty acids (SCFA), to influence brain development, function and behavior. Emerging evidence suggests that the gut microbiota may play a role in shaping cognitive networks encompassing emotional and social domains in neurodevelopmental disorders. Drawing upon pre-clinical and clinical evidence, we review the potential role of the gut microbiota in the origins and development of social and emotional domains related to Autism spectrum disorders (ASD) and schizophrenia. Small preliminary clinical studies have demonstrated gut microbiota alterations in both ASD and schizophrenia compared to healthy controls. However, we await the further development of mechanistic insights, together with large scale longitudinal clinical trials, that encompass a systems level dimensional approach, to investigate whether promising pre-clinical and initial clinical findings lead to clinical relevance.en
dc.description.sponsorshipHealth Research Board (HRA_POR/2011/23; HRA_POR/2012/32; HRA-POR-2-14-647); Brain and Behavior Research Foundation (Grant Number 20771 NARSAD Young Investigator Grant).en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid490
dc.identifier.citationKelly, J. R., Minuto, C., Cryan, J. F., Clarke, G. and Dinan, T. G. (2017) 'Cross talk: the microbiota and neurodevelopmental disorders', Frontiers in Neuroscience, 11, 490 (31pp). doi: 10.3389/fnins.2017.00490en
dc.identifier.doi10.3389/fnins.2017.00490
dc.identifier.endpage31
dc.identifier.issn1662-4548
dc.identifier.issn1662-453X
dc.identifier.journaltitleFrontiers in Neuroscienceen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/4899
dc.identifier.volume11
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fnins.2017.00490/full
dc.rights© 2017, Kelly, Minuto, Cryan, Clarke and Dinan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these termsen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMicrobiotaen
dc.subjectMicrobiomeen
dc.subjectGut-brain axisen
dc.subjectImmune systemen
dc.subjectSocial cognitionen
dc.subjectAutismen
dc.subjectSchizophreniaen
dc.subjectPsychobioticsen
dc.titleCross talk: the microbiota and neurodevelopmental disordersen
dc.typeArticle (peer-reviewed)en
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