Examining the healthy human microbiome concept

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dc.check.date2025-04-23
dc.check.infoAccess to this article is restricted until 6 months after publication by request of the publisheren
dc.contributor.authorJoos, Raphaelaen
dc.contributor.authorBoucher, Katyen
dc.contributor.authorLavelle, Aonghusen
dc.contributor.authorArumugam, Manimozhiyanen
dc.contributor.authorBlaser, Martin J.en
dc.contributor.authorClaesson, Marcus J.en
dc.contributor.authorClarke, Gerarden
dc.contributor.authorCotter, Paul D.en
dc.contributor.authorDe Sordi, Luisaen
dc.contributor.authorDominguez-Bello, Maria G.en
dc.contributor.authorDutilh, Bas E.en
dc.contributor.authorEhrlich, Stanislav D.en
dc.contributor.authorGhosh, Tarini Shankaren
dc.contributor.authorHill, Colinen
dc.contributor.authorJunot, Christopheen
dc.contributor.authorLahti, Leoen
dc.contributor.authorLawley, Trevor D.en
dc.contributor.authorLicht, Tine R.en
dc.contributor.authorMaguin, Emmanuelleen
dc.contributor.authorMakhalanyane, Thulani P.en
dc.contributor.authorMarchesi, Julian R.en
dc.contributor.authorMatthijnssens, Jelleen
dc.contributor.authorRaes, Jeroenen
dc.contributor.authorRavel, Jacquesen
dc.contributor.authorSalonen, Anneen
dc.contributor.authorScanlan, Pauline D.en
dc.contributor.authorShkoporov, Andreyen
dc.contributor.authorStanton, Catherineen
dc.contributor.authorThiele, Inesen
dc.contributor.authorTolstoy, Igoren
dc.contributor.authorWalter, Jensen
dc.contributor.authorYang, Boen
dc.contributor.authorYutin, Nataliaen
dc.contributor.authorZhernakova, Alexandraen
dc.contributor.authorZwart, Huben
dc.contributor.authorAsnicar, Francescoen
dc.contributor.authorTypas, Athanasiosen
dc.contributor.authorBetsou, Fayen
dc.contributor.authorBlottière, Hervéen
dc.contributor.authorBork, Peeren
dc.contributor.authorBoutron, Isabelleen
dc.contributor.authorCarraturo, Federicaen
dc.contributor.authorClaesson, Marcusen
dc.contributor.authorCordaillat-Simmons, Magalien
dc.contributor.authorDruart, Celineen
dc.contributor.authorFasano, Alessioen
dc.contributor.authorGodoy, Yolandaen
dc.contributor.authorHaller, Dirken
dc.contributor.authorHassani, Zahraen
dc.contributor.authorHazenbrink, Diënty H. M. J.en
dc.contributor.authorIsraelsen, Madsen
dc.contributor.authorIyappan, Anandhien
dc.contributor.authorJarde, Alexanderen
dc.contributor.authorKampshoff, Stephanen
dc.contributor.authorKrag, Aleksanderen
dc.contributor.authorKriaa, Aichaen
dc.contributor.authorLavelle, Aonghusen
dc.contributor.authorMetwaly, Amiraen
dc.contributor.authorMorozova, Vitalinaen
dc.contributor.authorPinto, Federicaen
dc.contributor.authorPons, Nicolasen
dc.contributor.authorProst, Pierre-Louisen
dc.contributor.authorRavaud, Philippeen
dc.contributor.authorRhimi, Moezen
dc.contributor.authorRodriquez, Julieen
dc.contributor.authorSarati, Arjunen
dc.contributor.authorSchierwagen, Roberten
dc.contributor.authorSegata, Nicolaen
dc.contributor.authorSerra, Deboraen
dc.contributor.authorTrebicka, Jonelen
dc.contributor.authorVecchi, Corradoen
dc.contributor.authorVeiga, Patricken
dc.contributor.authorZitvogel, Laurenceen
dc.contributor.authorDerosa, Lisaen
dc.contributor.authorDoré, Joëlen
dc.contributor.authorRoss, R. Paulen
dc.contributor.funderHorizon 2020en
dc.date.accessioned2024-12-02T15:55:26Z
dc.date.available2024-12-02T15:55:26Z
dc.date.issued2024-10-23en
dc.description.abstractHuman microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a ‘healthy’ human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome–health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJoos, R., Boucher, K., Lavelle, A., Arumugam, M., Blaser, M. J., Claesson, M. J., Clarke, G., Cotter, P. D., De Sordi, L., Dominguez-Bello, M. G., Dutilh, B. E., Ehrlich, S. D., Ghosh, T. S., Hill, C., Junot, C., Lahti, L., Lawley, T. D., Licht, T. R., Maguin, E., Makhalanyane, T. P., Marchesi, J. R., Matthijnssens, J., Raes, J., Ravel, J., Salonen, A., Scanlan, P. D., Shkoporov, A., Stanton, C., Thiele, I., Tolstoy, I., Walter, J., Yang, B., Yutin, N., Zhernakova, A., Zwart, H., Doré J. and Ross, R. P. (2024) 'Examining the healthy human microbiome concept', Nature Reviews Microbiology, pp.1-14. https://doi.org/10.1038/s41579-024-01107-0en
dc.identifier.doihttps://doi.org/10.1038/s41579-024-01107-0en
dc.identifier.eissn1740-1534en
dc.identifier.endpage14en
dc.identifier.issn1740-1526en
dc.identifier.journaltitleNature Reviews Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/16696
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.ispartofNature Reviews Microbiologyen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::CSA/964590/EU/International Human Microbiome Coordination and Support Action/IHMCSAen
dc.rights© 2024, This version of the paper has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41579-024-01107-0en
dc.subjectHuman microbiomeen
dc.subjectMicrobiome-health relationshipen
dc.subjectMicrobial communitiesen
dc.titleExamining the healthy human microbiome concepten
dc.typeArticle (peer-reviewed)en
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