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Examining the healthy human microbiome concept
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Date
2024-10-23
Authors
Joos, Raphaela
Boucher, Katy
Lavelle, Aonghus
Arumugam, Manimozhiyan
Blaser, Martin J.
Claesson, Marcus J.
Clarke, Gerard
Cotter, Paul D.
De Sordi, Luisa
Dominguez-Bello, Maria G.
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Nature
Published Version
Abstract
Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a ‘healthy’ human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome–health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.
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Keywords
Human microbiome , Microbiome-health relationship , Microbial communities
Citation
Joos, R., Boucher, K., Lavelle, A., Arumugam, M., Blaser, M. J., Claesson, M. J., Clarke, G., Cotter, P. D., De Sordi, L., Dominguez-Bello, M. G., Dutilh, B. E., Ehrlich, S. D., Ghosh, T. S., Hill, C., Junot, C., Lahti, L., Lawley, T. D., Licht, T. R., Maguin, E., Makhalanyane, T. P., Marchesi, J. R., Matthijnssens, J., Raes, J., Ravel, J., Salonen, A., Scanlan, P. D., Shkoporov, A., Stanton, C., Thiele, I., Tolstoy, I., Walter, J., Yang, B., Yutin, N., Zhernakova, A., Zwart, H., Doré J. and Ross, R. P. (2024) 'Examining the healthy human microbiome concept', Nature Reviews Microbiology, pp.1-14. https://doi.org/10.1038/s41579-024-01107-0
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Copyright
© 2024, This version of the paper has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41579-024-01107-0