Bifidobacterium and Lactobacillus composition at species level and gut microbiota diversity in infants before 6 weeks

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dc.contributor.authorYang, Bo
dc.contributor.authorChen, Yingqi
dc.contributor.authorStanton, Catherine
dc.contributor.authorRoss, R. Paul
dc.contributor.authorLee, Yuan-Kun
dc.contributor.authorZhao, Jianxin
dc.contributor.authorZhang, Hao
dc.contributor.authorChen, Wei
dc.contributor.funderNational Natural Science Foundation of Chinaen
dc.contributor.funderChinese Institute of Food Science and Technology-Scitop Bio-Tech Funding programen
dc.contributor.funderCollaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Provinceen
dc.contributor.funderNational First-Class Discipline Program of Food Science and Technologyen
dc.date.accessioned2019-09-23T09:53:14Z
dc.date.available2019-09-23T09:53:14Z
dc.date.issued2019-07-05
dc.description.abstractOur objective was to investigate the effects of different delivery and feeding modes on the gut microbiota composition of early infants with special emphasis on Bifidobacterium and Lactobacillus profiles at species level. 16S rRNA V3-V4 regions, bifidobacterial, and lactobacilli groEL genes from infant feces were sequenced by Illumina MiSeq. Gut microbiota abundance was significantly different, where standard vaginally delivered (SVD) and breast-fed (BF) groups were higher in comparison with caesarean section (CS), milk-powder-fed (MPF), and mixed-fed (MF) groups. The genus unclassified Enterobacteriaceae was dominant, followed by Bifidobacterium, which was highly abundant in SVD and BF groups. The dominant Bifidobacterium species in all groups were B. longum subsp. longum, B. longum subsp. infantis and B. animalis subsp. lactis. B. dentium and the diversity of Bifidobacterium in SVD and BF groups were significantly higher. For Lactobacillus profiles, L. rhamnosus and L. gasseri were dominant among all the groups, while Lactobacillus species in CS and MPF groups were more diverse. Functional predictions showed significant differences between delivery mode and feeding groups, such as phosphotransferase system as well as taurine and hypotaurine metabolism. In early infants with different delivery and feeding methods, gut microbiota—particularly bifidobacteria and lactobacilli communities—showed significant differences, with strong implications for physiological functions.en
dc.description.sponsorshipNational Natural Science Foundation of China (Nos. 31771953, 31820103010); National First-Class Discipline Program of Food Science and Technology (JUFSTR20180102)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid3306en
dc.identifier.citationYang, B., Chen, Y., Stanton, C., Ross, R. P., Lee, Y.-K., Zhao, J., Zhang, H. and Chen, W. (2019) 'Bifidobacterium and Lactobacillus Composition at Species Level and Gut Microbiota Diversity in Infants before 6 Weeks', International Journal of Molecular Sciences, 20(13). (16pp.) 3306. DOI: 10.3390/ijms20133306en
dc.identifier.doi10.3390/ijms20133306en
dc.identifier.eissn1422-0067
dc.identifier.endpage16en
dc.identifier.issn1661-6596
dc.identifier.issued10en
dc.identifier.journaltitleInternational Journal of Molecular Sciencesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8591
dc.identifier.volume20en
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.urihttps://www.mdpi.com/1422-0067/20/13/3306/htm
dc.rights©2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectGut microbiotaen
dc.subjectBifidobacterium communitiesen
dc.subjectLactobacillus communitiesen
dc.subjectDiversityen
dc.subjectInfantsen
dc.subjectFunctional predictionen
dc.titleBifidobacterium and Lactobacillus composition at species level and gut microbiota diversity in infants before 6 weeksen
dc.typeArticle (peer-reviewed)en
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