Ultra-low-dose thoracic CT with model-based iterative reconstruction (MBIR) in cystic fibrosis patients undergoing treatment with cystic fibrosis transmembrane conductance regulators (CFTR)

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dc.contributor.authorMoloney, Fiachra
dc.contributor.authorKavanagh, Richard G.
dc.contributor.authorRonan, Nicola J.
dc.contributor.authorGrey, T. M.
dc.contributor.authorJoyce, Stella
dc.contributor.authorRyan, David J.
dc.contributor.authorMoore, Niamh
dc.contributor.authorO'Connor, Owen J.
dc.contributor.authorPlant, Barry J.
dc.contributor.authorMaher, Michael M.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2021-10-05T10:46:20Z
dc.date.available2021-10-05T10:46:20Z
dc.date.issued2021-01-16
dc.date.updated2021-10-04T14:50:13Z
dc.description.abstractAIM: To assess the utility of a volumetric low-dose computed tomography (CT) thorax (LDCTT) protocol at a dose equivalent to a posteroanterior (PA) and lateral chest radiograph for surveillance of cystic fibrosis (CF) patients. MATERIALS AND METHODS: A prospective study was undertaken of 19 adult patients with CF that proceeded to LDCTT at 12 and 24 months following initiation of ivacaftor. A previously validated seven-section, low-dose axial CT protocol was used for the 12-month study. A volumetric LDCTT protocol was developed for the 24-month study and reconstructed with hybrid iterative reconstruction (LD-ASIR) and pure iterative reconstruction (model-based IR [LD-MBIR]). Radiation dose was recorded for each scan. Image quality was assessed quantitatively and qualitatively, and disease severity was assessed using a modified Bhalla score. Statistical analysis was performed and p-values of <0.05 were considered statistically significant. RESULTS: Volumetric LD-MBIR studies were acquired at a lower radiation dose than the seven-section studies (0.08 ± 0.01 versus 0.10 ± 0.02 mSv; p=0.02). LD-MBIR and seven-section ASIR images had significantly lower levels of image noise compared with LD-ASIR images (p<0.0001). Diagnostic acceptability scores and depiction of bronchovascular structures were found to be acceptable for axial and coronal LD-MBIR images. LD-MBIR images were superior to LD-ASIR images for all qualitative parameters assessed (p<0.0001). No significant change was observed in mean Bhalla score between 1-year and 2-year studies (p=0.84). CONCLUSIONS: The use of a volumetric LDCTT protocol (reconstructed with pure IR) enabled acquisition of diagnostic quality CT images, which were considered extremely useful for surveillance of CF patients, at a dose equivalent to a PA and lateral chest radiograph.en
dc.description.sponsorshipScience Foundation Ireland (centre research grant to APC Microbiome, UCC, Cork, Ireland)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid393.een
dc.identifier.citationMoloney, F., Kavanagh, R.G., Ronan, N.J., Grey, T. M., Joyce, S., Ryan, D.J., Moore, N., O'Connor, O.J., Plant, B. J. and Maher, M. M. (2021) 'Ultra-low-dose thoracic CT with model-based iterative reconstruction (MBIR) in cystic fibrosis patients undergoing treatment with cystic fibrosis transmembrane conductance regulators (CFTR)', Clinical Radiology, 76(5), pp. 393.e9 - 393.e17. doi: 10.1016/j.crad.2020.12.003en
dc.identifier.doi10.1016/j.crad.2020.12.003en
dc.identifier.eissn1365-229X
dc.identifier.endpage393.e17en
dc.identifier.issn0009-9260
dc.identifier.issued5en
dc.identifier.journaltitleClinical Radiologyen
dc.identifier.startpage393.e9en
dc.identifier.urihttps://hdl.handle.net/10468/12049
dc.identifier.volume76en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.rights© 2021, the Authors. Published by Elsevier Ltd on behalf of The Royal College of Radiologists. This is an open access article under the CC BY license.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMBIR CFTRen
dc.titleUltra-low-dose thoracic CT with model-based iterative reconstruction (MBIR) in cystic fibrosis patients undergoing treatment with cystic fibrosis transmembrane conductance regulators (CFTR)en
dc.typeArticle (peer-reviewed)en
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