Maternal antibiotic administration during a critical developmental window has enduring neurobehavioural effects in offspring mice

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dc.contributor.authorO'Connor, Rory
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorFulling, Christine
dc.contributor.authorO'Riordan, Kenneth J.
dc.contributor.authorFitzgerald, Patrick
dc.contributor.authorBastiaanssen, Thomaz F. S.
dc.contributor.authorSchellekens, Harriƫt
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2022-03-25T11:48:43Z
dc.date.available2022-03-25T11:48:43Z
dc.date.issued2021-04
dc.date.updated2022-03-25T11:14:40Z
dc.description.abstractRates of perinatal maternal antibiotic use have increased in recent years linked to prophylactic antibiotic use following Caesarean section delivery. This antibiotic use is necessary and beneficial in the short-term; however, long-term consequences on brain and behaviour have not been studied in detail. Here, we endeavoured to determine whether maternal administration of antibiotics during a critical window of development in early life has lasting effects on brain and behaviour in offspring mice. To this end we studied two different antibiotic preparations (single administration of Phenoxymethylpenicillin at 31 mg/kg/day; and a cocktail consisting of, ampicillin 1 mg/mL; vancomycin 0.5 mg/mL; metronidazole 1 mg/mL; ciprofloxacin 0.2 mg/mL and imipenem 0.25 mg/mL). It was observed that early life exposure to maternal antibiotics led to persistent alterations in anxiety, sociability and cognitive behaviours. These effects in general were greater in animals treated with the broad-spectrum antibiotic cocktail compared to a single antibiotic with the exception of deficits in social recognition which were more robustly observed in Penicillin V exposed animals. Given the prevalence of maternal antibiotic use, our findings have potentially significant translational relevance, particularly considering the implications on infant health during this critical period and into later life.en
dc.description.sponsorshipScience Foundation Ireland (Grants SFI/12/RC/ 2273_P2)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid113156en
dc.identifier.citationO'Connor, R., Moloney, G. M., Fulling, C., O'Riordan, K. J., Fitzgerald, P., Bastiaanssen, T. F. S., Schellekens, H., Dinan, T. G. and Cryan, J. F. (2021) 'Maternal antibiotic administration during a critical developmental window has enduring neurobehavioural effects in offspring mice', Behavioural Brain Research, 404, 113156 (13pp). doi: 10.1016/j.bbr.2021.113156en
dc.identifier.doi10.1016/j.bbr.2021.113156en
dc.identifier.endpage13en
dc.identifier.issn0166-4328
dc.identifier.journaltitleBehavioural Brain Researchen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/12990
dc.identifier.volume404en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rightsĀ© 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectGut microbiota depletionen
dc.subjectIntestinal microbiotaen
dc.subjectMouse modelen
dc.subjectBrainen
dc.subjectLifeen
dc.subjectAnxietyen
dc.subjectBehavioren
dc.subjectMetronidazoleen
dc.subjectAdulthooden
dc.subjectAsthmaen
dc.subjectDevelopmenten
dc.subjectAntibioticen
dc.subjectBehaviouren
dc.subjectCognitionen
dc.subjectCritical windowen
dc.titleMaternal antibiotic administration during a critical developmental window has enduring neurobehavioural effects in offspring miceen
dc.typeArticle (peer-reviewed)en
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