Nisin Z and lacticin 3147 improve efficacy of antibiotics against clinically significant bacteria
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Date
2019
Authors
Ellis, Jenna-Claire
Ross, R. Paul
Hill, Colin
Journal Title
Journal ISSN
Volume Title
Publisher
Future Medicine
Published Version
Abstract
Aim: To determine if bacteriocins improve antibiotic efficacy. Materials & methods: Deferred antagonism assays identified bacteriocins with activity. Growth curves and time kill assays demonstrated bactericidal activity of antimicrobial combinations, and checkerboard assays confirmed synergy. Methicillin-resistant Staphylococcus aureus-infected porcine skin model determined ex vivo efficacy. Results: Subinhibitory concentrations of lacticin with penicillin or vancomycin resulted in complete growth inhibition of strains and the improved inhibitory effect was apparent after 1 h. Nisin with methicillin proved more effective against methicillin-resistant Staphylococcus aureus than either antimicrobial alone, revealing partial synergy and significantly reduced pathogen numbers on porcine skin after 3 h compared with minimal inhibition for either antimicrobial alone. Conclusion: Nisin Z and lacticin 3147 may support the use of certain antibiotics and revive ineffective antibiotics.
Description
Keywords
Antibiotics , Antimicrobial , Bacteriocins , Lacticin 3147 , Methicillin , Nisin Z , Pathogen , Penicillin , Synergy , Vancomycin
Citation
Ellis, J.-C., Ross, R.P. and Hill, C. (2019) ‘Nisin Z and lacticin 3147 improve efficacy of antibiotics against clinically significant bacteria’, Future Microbiology, 14(18), pp. 1573–1587. doi: 10.2217/fmb-2019-0153