Nisin Z and lacticin 3147 improve efficacy of antibiotics against clinically significant bacteria

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dc.contributor.authorEllis, Jenna-Claire
dc.contributor.authorRoss, R. Paul
dc.contributor.authorHill, Colin
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2024-03-25T15:48:35Z
dc.date.available2024-03-25T15:48:35Z
dc.date.issued2019en
dc.description.abstractAim: To determine if bacteriocins improve antibiotic efficacy. Materials & methods: Deferred antagonism assays identified bacteriocins with activity. Growth curves and time kill assays demonstrated bactericidal activity of antimicrobial combinations, and checkerboard assays confirmed synergy. Methicillin-resistant Staphylococcus aureus-infected porcine skin model determined ex vivo efficacy. Results: Subinhibitory concentrations of lacticin with penicillin or vancomycin resulted in complete growth inhibition of strains and the improved inhibitory effect was apparent after 1 h. Nisin with methicillin proved more effective against methicillin-resistant Staphylococcus aureus than either antimicrobial alone, revealing partial synergy and significantly reduced pathogen numbers on porcine skin after 3 h compared with minimal inhibition for either antimicrobial alone. Conclusion: Nisin Z and lacticin 3147 may support the use of certain antibiotics and revive ineffective antibiotics.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationEllis, J.-C., Ross, R.P. and Hill, C. (2019) ‘Nisin Z and lacticin 3147 improve efficacy of antibiotics against clinically significant bacteria’, Future Microbiology, 14(18), pp. 1573–1587. doi: 10.2217/fmb-2019-0153en
dc.identifier.doi10.2217/fmb-2019-0153en
dc.identifier.endpage1587en
dc.identifier.issn1746-0913en
dc.identifier.issued17en
dc.identifier.journaltitleFuture Microbiologyen
dc.identifier.startpage1573en
dc.identifier.urihttps://hdl.handle.net/10468/15698
dc.identifier.volume14en
dc.language.isoenen
dc.publisherFuture Medicineen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2020 Colin Hill. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectAntibioticsen
dc.subjectAntimicrobialen
dc.subjectBacteriocinsen
dc.subjectLacticin 3147en
dc.subjectMethicillinen
dc.subjectNisin Zen
dc.subjectPathogenen
dc.subjectPenicillinen
dc.subjectSynergyen
dc.subjectVancomycinen
dc.titleNisin Z and lacticin 3147 improve efficacy of antibiotics against clinically significant bacteriaen
dc.typeArticle (peer-reviewed)en
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