IL-1 family members in cancer; two sides to every story

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dc.contributor.authorBaker, Kevin J.
dc.contributor.authorHouston, Aileen M.
dc.contributor.authorBrint, Elizabeth K.
dc.contributor.funderIrish Research Councilen
dc.date.accessioned2019-09-04T15:44:14Z
dc.date.available2019-09-04T15:44:14Z
dc.date.issued2019-06-07
dc.date.updated2019-09-02T06:12:19Z
dc.description.abstractThe IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in modulating both the innate and adaptive immunes response, with dysregulation linked to a variety of autoimmune and inflammatory diseases. Given the increasing appreciation of the link between inflammation and cancer, the role of several members of this family in the pathogenesis of cancer has been extensively investigated. In this review, we highlight both the pro- and anti-tumorigenic effects identified for almost all members of this family, and explore potential underlying mechanisms accounting for these divergent effects. Such dual functions need to be carefully assessed when developing therapeutic intervention strategies targeting these cytokines in cancer.en
dc.description.sponsorshipIrish Research Council (Government of Ireland grant (GOIPG/2018/2974))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1197en
dc.identifier.citationBaker, K. J., Houston, A. and Brint, E. (2019) 'IL-1 Family Members in Cancer; Two Sides to Every Story', Frontiers in Immunology, 10, 1197 (16 pp). doi: 10.3389/fimmu.2019.01197en
dc.identifier.doi10.3389/fimmu.2019.01197en
dc.identifier.endpage16en
dc.identifier.issn1664-3224
dc.identifier.journaltitleFrontiers In Immunologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8454
dc.identifier.volume10en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.rights© 2019 Baker, Houston and Brint. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectInterleukin-1 (IL-1)en
dc.subjectInflammationen
dc.subjectCanceren
dc.subjectIL-18en
dc.subjectIL-33en
dc.subjectIL-36 family interleukinsen
dc.subjectPredicts poor prognosisen
dc.subjectInhibits tumor growthen
dc.subjectNatural killer cellsen
dc.subjectPancreatic canceren
dc.subjectOvarian canceren
dc.subjectT-cellsen
dc.subjectSerum interleukin-18en
dc.subjectMetastatic phenotypeen
dc.subjectAcquired immunityen
dc.titleIL-1 family members in cancer; two sides to every storyen
dc.typeArticle (peer-reviewed)en
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