Oxysterols, age-related-diseases and nutritherapy: Focus on 7-ketocholesterol and 7β-hydroxycholesterol

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dc.contributor.authorVejux, Anneen
dc.contributor.authorGhzaiel, Imenen
dc.contributor.authorMackrill, John J.en
dc.contributor.authorDias, Irundika H.K.en
dc.contributor.authorRezig, Leilaen
dc.contributor.authorKsila, Mohameden
dc.contributor.authorZarrouk, Amiraen
dc.contributor.authorNury, Thomasen
dc.contributor.authorBrahmi, Fatihaen
dc.contributor.authorEl Midaoui, Adilen
dc.contributor.authorMeziane, Smailen
dc.contributor.authorAtanasov, Atanas G.en
dc.contributor.authorHammami, Soniaen
dc.contributor.authorLatruffe, Norberten
dc.contributor.authorJouanny, Pierreen
dc.contributor.authorLizard, Gérarden
dc.contributor.funderINPSTen
dc.contributor.funderMediterranean Association of Biogerontologyen
dc.contributor.funderUniversité de Bourgogne Europeen
dc.contributor.funderAssociation Bourguignonne pour les Applications des Sciences de l’Information en Médecineen
dc.contributor.funderABASIMen
dc.contributor.funderENORen
dc.contributor.funderUniversité de Tunis El Manar, UTMen
dc.contributor.funderPHC Utiqueen
dc.contributor.funderAssociation Bourguignonne pour les Applications des Sciences de l'Information en Médecineen
dc.contributor.funderUniversité de Monastirfr
dc.date.accessioned2025-04-30T08:44:44Z
dc.date.available2025-04-30T08:44:44Z
dc.date.issued2025en
dc.description.abstractAge-related diseases are often associated with a disruption of RedOx balance that can lead to lipid peroxidation with the formation of oxysterols, especially those oxidized on carbon-7: 7-ketocholesterol (also known as 7-oxo-cholesterol) and 7β-hydroxycholesterol. Like cholesterol, these oxysterols have 27 carbons, they are composed of a sterane nucleus and have a hydroxyl function in position 3. The oxysterols 7-ketocholesterol and 7β-hydroxycholesterol are mainly formed by cholesterol autoxidation and are biomarkers of oxidative stress. These two oxysterols are frequently found at increased levels in the biological fluids (plasma, cerebrospinal fluid), tissues and/or organs (arterial wall, retina, brain) of patients with age-related diseases, especially cardiovascular diseases, neurodegenerative diseases (mainly Alzheimer's disease), ocular diseases (cataract, age-related macular degeneration), and sarcopenia. Depending on the cell type considered, 7-ketocholesterol and 7β-hydroxycholesterol induce either caspase- dependent or -independent types of cell death associated with mitochondrial and peroxisomal dysfunctions, autophagy and oxidative stress. The caspase dependent type of cell death associated with oxidative stress and autophagy is defined as oxiapoptophagy. These two oxysterols are also inducers of inflammation. These biological features associated with the toxicity of 7-ketocholesterol, and 7β-hydroxycholesterol are often observed in patients with age-related diseases, suggesting an involvement of these oxysterols in the pathophysiology of these disorders. The cytotoxic effects of 7-ketocholesterol and 7β-hydroxycholesterol are counteracted on different cell models by representative nutrients of the Mediterranean diet: ω3 and ω9 fatty acids, polyphenols, and tocopherols. There are also evidences, mainly in cardiovascular diseases, of the benefits of α-tocopherol and phenolic compounds. These in vitro and in vivo observations on 7-ketocholesterol and 7β-hydroxycholesterol, which are frequently increased in age-related diseases, reinforce the interest of nutritherapeutic treatments to prevent and/or cure age-related diseases currently without effective therapies.en
dc.description.sponsorshipPHC Utique, (47608VJ, 22G0809); Association Bourguignonne pour les Applications des Sciences de l'Information en Médecine, (180; 181)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid106993en
dc.identifier.citationVejux, A., Ghzaiel, I., Mackrill, J. J., Dias, I. H., Rezig, L., Ksila, M., Zarrouk, A., Nury, T., Brahmi, F., El Midaoui, A. and Meziane, S. (2025) 'Oxysterols, age-related-diseases and nutritherapy: focus on 7-ketocholesterol and 7β-hydroxycholesterol', Prostaglandins & Other Lipid Mediators, 178, p.106993. DOI: 10.1016/j.prostaglandins.2025.106993en
dc.identifier.doi10.1016/j.prostaglandins.2025.106993en
dc.identifier.issn10988823en
dc.identifier.journaltitleProstaglandins and Other Lipid Mediatorsen
dc.identifier.urihttps://hdl.handle.net/10468/17367
dc.identifier.volume178
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.relation.project47608VJ
dc.relation.project22G0809
dc.relation.project180
dc.relation.project181
dc.rights© 2025, the Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subject7-ketocholesterolen
dc.subject7?-hydroxycholesterolen
dc.subjectAge-related diseasesen
dc.subjectBiomarkersen
dc.subjectMediterranean dieten
dc.subjectNutrientsen
dc.subjectNutritherapyen
dc.subjectOxiapoptophagyen
dc.subjectOxysterolen
dc.titleOxysterols, age-related-diseases and nutritherapy: Focus on 7-ketocholesterol and 7β-hydroxycholesterolen
dc.typeArticle (peer reviewed)en
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