Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population

Phillips, Catherine M.; Kearney, Patricia M.; McCarthy, Vera J. C.; Harrington, Janas M.; Fitzgerald, Anthony P.; Perry, Ivan J.

Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population

dc.contributor.author	Phillips, Catherine M.
dc.contributor.author	Kearney, Patricia M.
dc.contributor.author	McCarthy, Vera J. C.
dc.contributor.author	Harrington, Janas M.
dc.contributor.author	Fitzgerald, Anthony P.
dc.contributor.author	Perry, Ivan J.
dc.contributor.funder	Health Research Board
dc.date.accessioned	2016-02-17T11:45:31Z
dc.date.available	2016-02-17T11:45:31Z
dc.date.issued	2013
dc.description.abstract	Background: To compare diabetes risk assessment tools in estimating risk of developing type 2 diabetes (T2DM) and to evaluate cardiometabolic risk profiles in a middle-aged Irish population. Methods: Future risk of developing T2DM was estimated using 7 risk scores, including clinical measures with or without anthropometric, biological and lifestyle data, in the cross-sectional Mitchelstown cohort of 2,047 middle-aged men and women. Cardiometabolic phenotypes including markers of glucose metabolism, inflammatory and lipid profiles were determined. Results: Estimates of subjects at risk for developing T2DM varied considerably according to the risk assessment tool used (0.3% to 20%), with higher proportions of males at risk (0-29.2% vs. 0.1-13.4%, for men and women, respectively). Extrapolated to the Irish population of similar age, the overall number of adults at high risk of developing T2DM ranges from 3,378 to 236,632. Numbers of non-optimal metabolic features were generally greater among those at high risk of developing T2DM. However, cardiometabolic profile characterisation revealed that only those classified at high risk by the Griffin (UK Cambridge) score displayed a more pro-inflammatory, obese, hypertensive, dysglycaemic and insulin resistant metabolic phenotype. Conclusions: Most diabetes risk scores examined offer limited ability to identify subjects with metabolic abnormalities and at risk of developing T2DM. Our results highlight the need to validate diabetes risk scoring tools for each population studied and the potential for developing an Irish diabetes risk score, which may help to promote self awareness and identify high risk individuals and diabetes hot spots for targeted public health interventions.	en
dc.description.sponsorship	Health Research Board (Grant No. HRC/2007/13)	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	e78950
dc.identifier.citation	Phillips CM, Kearney PM, McCarthy VJ, Harrington JM, Fitzgerald AP, Perry IJ (2013) Comparison of Diabetes Risk Score Estimates and Cardiometabolic Risk Profiles in a Middle-Aged Irish Population. PLoS ONE 8(11): e78950. doi:10.1371/journal.pone.0078950
dc.identifier.doi	10.1371/journal.pone.0078950
dc.identifier.issn	1932-6203
dc.identifier.issued	11	en
dc.identifier.journaltitle	PLOS ONE	en
dc.identifier.uri	https://hdl.handle.net/10468/2356
dc.identifier.volume	8	en
dc.language.iso	en	en
dc.publisher	Public Library of Science	en
dc.rights	© 2015 Phillips et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.subject	Impaired glucose tolerance	en
dc.subject	Lifestyle intervention	en
dc.subject	Coronary heart disease	en
dc.subject	C-reactive protein	en
dc.subject	Insulin resistance	en
dc.subject	Cardiovascular disease	en
dc.subject	Physical activity	en
dc.subject	Dietary patterns	en
dc.subject	Meat intake	en
dc.subject	Type 2	en
dc.title	Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population	en
dc.type	Article (peer-reviewed)	en