Metabolomics for predicting fetal growth restriction: protocol for a systematic review and meta-analysis

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dc.contributor.authorLeite, Debora Farias Batista
dc.contributor.authorMorillon, Aude-Claire
dc.contributor.authorMelo Júnior, Elias F.
dc.contributor.authorSouza, Renato T.
dc.contributor.authorKhashan, Ali S.
dc.contributor.authorBaker, Philip N.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorCecatti, José Guilherme
dc.contributor.funderBill and Melinda Gates Foundationen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderCoordenação de Aperfeiçoamento de Pessoal de Nível Superioren
dc.date.accessioned2019-06-24T09:19:46Z
dc.date.available2019-06-24T09:19:46Z
dc.date.issued2018-12-06
dc.description.abstractIntroduction Fetal growth restriction (FGR) is a relevant research and clinical concern since it is related to higher risks of adverse outcomes at any period of life. Current predictive tools in pregnancy (clinical factors, ultrasound scan, placenta-related biomarkers) fail to identify the true growth-restricted fetus. However, technologies based on metabolomics have generated interesting findings and seem promising. In this systematic review, we will address diagnostic accuracy of metabolomics analyses in predicting FGR.Methods and analysis Our primary outcome is small for gestational age infant, as a surrogate for FGR, defined as birth weight below the 10th centile by customised or population-based curves for gestational age. A detailed systematic literature search will be carried in electronic databases and conference abstracts, using the keywords ‘fetal growth retardation’, ‘metabolomics’, ‘pregnancy’ and ‘screening’ (and their variations). We will include original peer-reviewed articles published from 1998 to 2018, involving pregnancies of fetuses without congenital malformations; sample collection must have been performed before clinical recognition of growth impairment. If additional information is required, authors will be contacted. Reviews, case reports, cross-sectional studies, non-human research and commentaries papers will be excluded. Sample characteristics and the diagnostic accuracy data will be retrieved and analysed. If data allows, we will perform a meta-analysis.Ethics and dissemination As this is a systematic review, no ethical approval is necessary. This protocol will be publicised in our institutional websites and results will be submitted for publication in a peer-reviewed journal.PROSPERO registration number CRD42018089985.en
dc.description.sponsorshipBrazilian National Research Council (401636/2013-5); Bill and Melinda Gates Foundation (grant number OPP1107597-Grand Challenges Brazil: Reducing the burden of preterm birth, Fiotec number 05/2013); Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES) (88881.134095/2016-01, 88881.134095/2016-0)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide022743en
dc.identifier.citationLeite, D.F.B., Morillon, A.C., Júnior, E.F.M., Souza, R.T., Khashan, A.S., Baker, P.N., Kenny, L.C. and Cecatti, J.G., 2018. Metabolomics for predicting fetal growth restriction: protocol for a systematic review and meta-analysis. BMJ open, 8(12), (e022743) DOI: 10.1136/bmjopen-2018-022743en
dc.identifier.doi10.1136/bmjopen-2018-022743en
dc.identifier.eissn1756-1833
dc.identifier.endpage5en
dc.identifier.issn0959-8138
dc.identifier.journaltitleBMJ Openen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8089
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.projectPRETERM-SAMBAen
dc.relation.urihttps://bmjopen.bmj.com/content/8/12/e022743
dc.rights© Author(s) (or their employer(s)) 2018. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See:https://creativecommons.org/licenses/by/4.0/.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectFetal growth restrictionen
dc.subjectPregnancyen
dc.subjectMetabolomicsen
dc.titleMetabolomics for predicting fetal growth restriction: protocol for a systematic review and meta-analysisen
dc.typeArticle (peer-reviewed)en
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