Probiotics and the microbiota-gut-brain axis: focus on psychiatry
| dc.contributor.author | Mörkl, Sabrina | |
| dc.contributor.author | Butler, Mary I. | |
| dc.contributor.author | Holl, Anna | |
| dc.contributor.author | Cryan, John F. | |
| dc.contributor.author | Dinan, Timothy G. | |
| dc.contributor.funder | Medizinische Universität Graz | en |
| dc.contributor.funder | Science Foundation Ireland | en |
| dc.date.accessioned | 2022-04-06T11:07:48Z | |
| dc.date.available | 2022-04-06T11:07:48Z | |
| dc.date.issued | 2020-09 | |
| dc.date.updated | 2022-04-06T10:38:24Z | |
| dc.description.abstract | Purpose of Review Probiotics are living bacteria, which when ingested in adequate amounts, confer health benefits. Gutmicrobes are suggested to play a role in many psychiatric disorders and could be a potential therapeutic target. Between the gut and the brain, there is a bi-directional communication pathway called the microbiota-gut-brain axis. The purpose of this review is to examine data from recent interventional studies focusing on probiotics and the gut-brain axis for the treatment of depression, anxiety and schizophrenia.Recent Findings Probiotics are likely to improve depression but not schizophrenia. Regarding anxiety, there is only one trial which showed an effect of a multispecies probiotic. However, determinants like the duration of treatment, dosage and interactions have not been thoroughly investigated and deserve more scientific attention.Summary Microbiome-based therapies such as probiotics could be cautiously recommended for depression to enhance beneficial bacteria in the gut and to improve mood through the gut-brain axis. | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Mörkl, S., Butler, M. I., Holl, A., Cryan, J. F. and Dinan, T. G. (2020) 'Probiotics and the microbiota-gut-brain axis: focus on psychiatry', Current Nutrition Reports, 9 (3) pp. 171-182. doi: 10.1007/s13668-020-00313-5 | en |
| dc.identifier.doi | 10.1007/s13668-020-00313-5 | en |
| dc.identifier.endpage | 182 | en |
| dc.identifier.issn | 2161-3311 | |
| dc.identifier.issued | 3 | en |
| dc.identifier.journaltitle | Current Nutrition Reports | en |
| dc.identifier.startpage | 171 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/13039 | |
| dc.identifier.volume | 9 | en |
| dc.language.iso | en | en |
| dc.publisher | Springer | en |
| dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
| dc.rights | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ | en |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Anxiety | en |
| dc.subject | Depression | en |
| dc.subject | Gut microbiota | en |
| dc.subject | Microbiota-gut-brain axis | en |
| dc.subject | Probiotics | en |
| dc.subject | Psychiatry | en |
| dc.subject | Schizophrenia | en |
| dc.subject | Vagal nerve | en |
| dc.title | Probiotics and the microbiota-gut-brain axis: focus on psychiatry | en |
| dc.type | Article (peer-reviewed) | en |
