When rhythms meet the blues: Circadian interactions with the microbiota-gut-brain axis

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dc.contributor.authorTeichman, Emily M.
dc.contributor.authorO'Riordan, Kenneth J.
dc.contributor.authorGahan, Cormac G. M.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSaks-Kavanaugh Foundation, United Statesen
dc.contributor.funderHorizon 2020en
dc.date.accessioned2020-04-02T12:12:04Z
dc.date.available2020-04-02T12:12:04Z
dc.date.issued2020-03-03
dc.date.updated2020-04-02T11:46:18Z
dc.description.abstractThe microbiota-gut-brain axis encompasses a bidirectional mode of communication between the microorganisms residing in our gut, and our brain function and behavior. The composition of the gut microbiota is subject to diurnal variation and is entrained by host circadian rhythms. In turn, a diverse microbiota is essential for optimal regulation of host circadian pathways. Disruption of the cyclical nature of this microbe-host interaction profoundly influences disease pathology and severity. This review aims to summarize current knowledge on this bidirectional relationship. Indeed, the past few years have revealed promising data regarding the relationship between the microbiota-gut-brain axis and circadian rhythms and how they act in concert to influence disease, but further research needs to be done to examine how they coalesce to modulate severity of, and risk for, certain diseases. Moreover, there is a need for a greater understanding of the molecular mechanisms underlying the close relationship between circadian-microbiome-brain interactions.en
dc.description.sponsorshipHorizon 2020 (DLV-848228DISCOvERIE Development, dIagnosis and prevention of gender-related Somatic andmental COmorbiditiEs in iRrItable bowel syndrome in Europe)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationTeichman, E. M., O'Riordan, K. J., Gahan, C. G. M., Dinan, T. G. and Cryan, J. F. (2020) 'When rhythms meet the blues: Circadian interactions with the microbiota-gut-brain axis', Cell Metabolism, 31(3), pp.448-471. doi: 10.1016/j.cmet.2020.02.008en
dc.identifier.doi10.1016/j.cmet.2020.02.008en
dc.identifier.eissn1932-7420
dc.identifier.endpage471en
dc.identifier.issn1550-4131
dc.identifier.issued3en
dc.identifier.journaltitleCell Metabolismen
dc.identifier.startpage448en
dc.identifier.urihttps://hdl.handle.net/10468/9811
dc.identifier.volume31en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2020, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCircadian rhythmen
dc.subjectMicrobiota-gut-brain axisen
dc.subjectMicrobiomeen
dc.subjectMicrobiotaen
dc.titleWhen rhythms meet the blues: Circadian interactions with the microbiota-gut-brain axisen
dc.typeArticle (peer-reviewed)en
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