Programming bugs: microbiota and the developmental origins of brain health and disease

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dc.contributor.authorCodagnone, Martin G.
dc.contributor.authorSpichak, Simon
dc.contributor.authorO'Mahony, Siobhain M.
dc.contributor.authorO'Leary, Olivia F.
dc.contributor.authorClarke, Gerard
dc.contributor.authorStanton, Catherine
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2020-02-13T16:58:41Z
dc.date.available2020-02-13T16:58:41Z
dc.date.issued2018-06-27
dc.date.updated2020-02-13T16:50:11Z
dc.description.abstractIt has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal events. It is clear that the interaction between genetic predisposition and early life environmental exposures is key in this regard. However, recent research has also identified another important factor in the microbiota—the trillions of microorganisms that inhabit key body niches, including the vagina and gastrointestinal tract. Because the composition of these maternal microbiome sites has been linked to maternal metabolism and is also vertically transmitted to offspring, changes in the maternal microbiota are poised to significantly affect the newborn. In fact, several lines of evidence show that the gut microbiota interacts with diet, drugs, and stress both prenatally and postnatally and that these exogenous factors could also affect the dynamic changes in the microbiota composition occurring during pregnancy. Animal models have shown great utility in illuminating how these disruptions result in behavioral and brain morphological phenotypes reminiscent of psychiatric disorders (anxiety, depression, schizophrenia, and autism spectrum disorders). Increasing evidence points to critical interactions among the microbiota, host genetics, and both the prenatal and postnatal environments to temporally program susceptibility to psychiatric disorders later in life. Sex-specific phenotypes may be programmed through the influence of the microbiota on the hypothalamic-pituitary-adrenal axis and neuroimmune system.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCodagnone, M. G., Spichak, S., O'Mahony, S. M., O’Leary, O. F., Clarke, G., Stanton, C., Dinan, T. G. and Cryan, J. F. (2019) 'Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease', Biological Psychiatry, 85(2), pp. 150-163. doi: 10.1016/j.biopsych.2018.06.014en
dc.identifier.doi10.1016/j.biopsych.2018.06.014en
dc.identifier.endpage163en
dc.identifier.issn0006-3223
dc.identifier.issued2en
dc.identifier.journaltitleBiological Psychiatryen
dc.identifier.startpage150en
dc.identifier.urihttps://hdl.handle.net/10468/9650
dc.identifier.volume85en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0006322318316056
dc.rights© 2018 Society of Biological Psychiatry. Published by Elsevier. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 licence.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectBrain developmenten
dc.subjectEarly lifeen
dc.subjectGut-brain axisen
dc.subjectMicrobiotaen
dc.subjectNeuropsychiatryen
dc.subjectStressen
dc.subject~Anatomy and Neuroscience - Journal Articles~en
dc.subject~Psychiatry - Journal Articles~en
dc.titleProgramming bugs: microbiota and the developmental origins of brain health and diseaseen
dc.typeArticle (peer-reviewed)en
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