Screening canine sources for novel antimicrobials reveals the circular broad-spectrum bacteriocin, caledonicin, produced by Staphylococcus caledonicus

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dc.contributor.authorO'Connor, Michelleen
dc.contributor.authorO'Connor, Paula M.en
dc.contributor.authorHourigan, Daviden
dc.contributor.authorMurray, Ellenen
dc.contributor.authorde Farias, Felipe Micelien
dc.contributor.authorField, Desen
dc.contributor.authorHill, Colinen
dc.contributor.authorRoss, R. Paulen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Commissionen
dc.date.accessioned2025-09-04T13:43:24Z
dc.date.available2025-09-04T13:43:24Z
dc.date.issued2024-08-26en
dc.description.abstractAntimicrobial-resistant pathogens present an ongoing threat to human and animal health, with deaths linked to antimicrobial resistance (AMR) predicted to increase annually. While the misuse and overuse of antibiotics in humans undoubtedly contribute to this escalation, antibiotic use in the veterinary field, including companion animals, also plays a contributing role. Pet owners’ desire to improve the quality of life of their pets is likely to support antibiotic use in this field. Consequently, there is a need for antibiotic alternatives to treat bacterial infections. This study set out to screen for antimicrobial peptides known as bacteriocins from bacterial isolates of aerobic/microaerophilic environments of canine sources and determine their potential as antibiotic alternatives against clinically relevant pathogens.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1470988en
dc.identifier.citationO'Connor, M., O’Connor, P.M., Hourigan, D., Murray, E., De Farias, F.M., Field, D., Hill, C. and Ross, R.P. (2024) ‘Screening canine sources for novel antimicrobials reveals the circular broad-spectrum bacteriocin, caledonicin, produced by Staphylococcus caledonicus’, Frontiers in Microbiology, 15, 1470988 (19pp). https://doi.org/10.3389/fmicb.2024.1470988en
dc.identifier.doi10.3389/fmicb.2024.1470988en
dc.identifier.eissn1664-302Xen
dc.identifier.endpage19en
dc.identifier.journaltitleFrontiers in Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/17823
dc.identifier.volume15en
dc.language.isoenen
dc.publisherFrontiers Media S.A.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA) - Training Award/10/IN.1/B3027 TIDA Training 11/IE/Lantibiotics: the next generation/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Research Centres Programme/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Research Centres Programme::Phase 2/12/RC/2273_P2/IE/APC_Phase 2/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/HE::ERC::HORIZON-ERC/101054719/EU/Bacteriocins from interbacterial warfare as antibiotic alternative/BACtheWINNERen
dc.rights© 2024 O'Connor, O’Connor, Hourigan, Murray, de Farias, Field, Hill and Ross. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAntimicrobial resistanceen
dc.subjectCanine microbiotaen
dc.subjectBacteriocinsen
dc.subjectCanine sourcesen
dc.subjectAntimicrobial potentialen
dc.subjectAntimicrobial peptidesen
dc.subject~Microbiology - Journal Articles~en
dc.titleScreening canine sources for novel antimicrobials reveals the circular broad-spectrum bacteriocin, caledonicin, produced by Staphylococcus caledonicusen
dc.typeArticle (peer-reviewed)en
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