Iron status, body size, and growth in the first 2 years of life

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dc.contributor.authorMcCarthy, Elaine K.
dc.contributor.authorNí­ Chaoimh, Carol E.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorHourihane, Jonathan O'B.
dc.contributor.authorIrvine, Alan D.
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorKiely, Mairead E.
dc.contributor.funderNational Children’s Research Centre, Irelanden
dc.contributor.funderFood Standards Agencyen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderDanoneen
dc.date.accessioned2019-02-18T16:50:34Z
dc.date.available2019-02-18T16:50:34Z
dc.date.issued2018-04-27
dc.date.updated2019-02-18T16:40:45Z
dc.description.abstractRapid growth in infancy has been shown to adversely affect iron status up to 1 year; however the effect of growth on iron status in the second year of life has been largely unexplored. We aimed to investigate the impact of growth and body size in the first 2 years on iron status at 2 years. In the prospective, maternal‐infant Cork BASELINE Birth Cohort Study, infant weight and length were measured at birth, 2, 6, 12, and 24 months and absolute weight (kg) and length (cm) gain from 0 to 2, 0 to 6, 0 to 12, 6 to 12, 12 to 24, and 0 to 24 months were calculated. At 2 years (n = 704), haemoglobin, mean corpuscular volume, and serum ferritin (umbilical cord concentrations also) were measured. At 2 years, 5% had iron deficiency (ferritin < 12 μg/L) and 1% had iron deficiency anaemia (haemoglobin < 110 g/L + ferritin < 12 μg/L). Weight gain from 6 to 12, 0 to 24, and 12 to 24 months were all inversely associated with ferritin concentrations at 2 years but only the association with weight gain from 12 to 24 months was robust after adjustment for potential confounders including cord ferritin (adj. estimate 95% CI: −4.40 [−8.43, −0.37] μg/L, p = .033). Length gain from 0 to 24 months was positively associated with haemoglobin at 2 years (0.42 [0.07, 0.76] g/L, p = .019), only prior to further adjustment for cord ferritin. To conclude, weight gain in the second year was inversely associated with iron stores at 2 years, even after accounting for iron status at birth. Further examinations of iron requirements, dietary intakes, and growth patterns in children in the second year of life in high‐resource settings are warranted.en
dc.description.sponsorshipHealth Research Board of Ireland (Grant/Award Number: CSA 02/2007); Danone (Danone Nutricia Early Life Nutrition)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMcCarthy, E. K., Ní Chaoimh, C., Kenny, L. C., Hourihane, J. O. B., Irvine, A. D., Murray, D. M. and Kiely, M. E. (2018) 'Iron status, body size, and growth in the first 2 years of life', Maternal & Child Nutrition, 14(1), e12458 (7 pp). doi: 10.1111/mcn.12458en
dc.identifier.doi10.1111/mcn.12458
dc.identifier.endpage7en
dc.identifier.issn1740-8695
dc.identifier.issued1en
dc.identifier.journaltitleMaternal & Child Nutritionen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/7514
dc.identifier.volume14en
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/mcn.12458
dc.rights© 2017 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: McCarthy EK, ní Chaoimh C, Kenny LC, et al. Iron status, body size, and growth in the first 2 years of life. Matern Child Nutr. 2018; 14: e12458, which has been published in final form at https://doi.org/10.1111/mcn.12458. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectBirth cohorten
dc.subjectBody sizeen
dc.subjectIron statusen
dc.subjectLength gainen
dc.subjectSerum ferritinen
dc.subjectWeight gainen
dc.titleIron status, body size, and growth in the first 2 years of lifeen
dc.typeArticle (peer-reviewed)en
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