Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype

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dc.contributor.author Dennison, Una
dc.contributor.author McKernan, Declan P.
dc.contributor.author Cryan, John F.
dc.contributor.author Dinan, Timothy G.
dc.date.accessioned 2013-02-27T17:51:17Z
dc.date.available 2013-02-27T17:51:17Z
dc.date.copyright 2012
dc.date.issued 2012
dc.identifier.citation U. Dennison, D. McKernan, J. Cryan and T. Dinan (2012). Schizophrenia patients with a history of childhood trauma have a proinflammatory phenotype. Psychological Medicine, 42(9), pp 1865-1871 doi:10.1017/S0033291712000074 en
dc.identifier.volume 42 en
dc.identifier.issued 9 en
dc.identifier.startpage 1865 en
dc.identifier.endpage 1871 en
dc.identifier.uri http://hdl.handle.net/10468/1000
dc.identifier.doi 10.1017/S0033291712000074
dc.description.abstract Background. Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. Method. We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1b, IL-6, IL-8 and tumour necrosis factor (TNF)-a. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls. Results. Patients with childhood trauma had higher levels of IL-6 and TNF-a than patients without trauma and healthy controls, and TNF-a levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls. Conclusions. Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype. en
dc.description.sponsorship Science Foundation Ireland (SFI-CSET); Science Foundation Ireland and GlaxoSmithKline, United Kingdom (07/CE/B1368) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Cambridge University Press en
dc.relation.uri http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8656043&fulltextType=RA&fileId=S0033291712000074
dc.rights © Cambridge University Press, 2012 en
dc.subject Schizophrenia en
dc.subject Childhood trauma en
dc.subject Pro-inflammatory Phenotype en
dc.subject ELISA techniques en
dc.subject Interleukin en
dc.subject Tumour necrosis Factor en
dc.subject Inflammation en
dc.title Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://research.ucc.ie/profiles/C009/tdinan en
dc.internal.authorcontactother Prof. Timothy G. Dinan, Psychiatry, GF Unit, Cork University Hospital, Wilton, Cork, Ireland. Email: t.dinan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder GlaxoSmithKline, United Kingdom en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Psychological Medicine en
dc.internal.copyrightchecked This is a Sherpa Romeo Green Jouranl. Policy: Institutional repositories - 2.4. The author may post the VoR version of the article (in PDF or HTML form) in the Institutional Repository of the institution in which the author worked at the time the article was first submitted, or (for appropriate journals) in PubMed Central or UK PubMed Central or arXiv, no sooner than one year after first publication of the article in the Journal, subject to file availability and provided the posting includes a prominent statement of the full bibliographical details, a copyright notice in the name of the copyright holder (Cambridge University Press or the sponsoring Society, as appropriate), and a link to the online edition of the Journal at Cambridge Journals Online. en
dc.internal.IRISemailaddress t.dinan@ucc.ie en


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