Isolation of Lactobacilli with probiotic properties from the human stomach

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dc.contributor.author Ryan, Kieran A.
dc.contributor.author Jayaraman, Thevaraajan
dc.contributor.author Daly, Paul
dc.contributor.author Canchaya, Carlos
dc.contributor.author Curran, Susan
dc.contributor.author Fang, Fang
dc.contributor.author Quigley, Eamonn M.
dc.contributor.author O'Toole, Paul W.
dc.date.accessioned 2010-02-15T10:35:00Z
dc.date.available 2010-02-15T10:35:00Z
dc.date.issued 2008-10
dc.identifier.citation Ryan, KA, Jayaraman, T, Daly, P, Canchaya, C, Curran, S, Fang, F, Quigley, EM, O'Toole, PW (2008) 'Isolation of Lactobacilli With Probiotic Properties From The Human Stomach'. Letters In Applied Microbiology, 47 (4):269-274. en
dc.identifier.volume 47 en
dc.identifier.issued 4 en
dc.identifier.startpage 269 en
dc.identifier.endpage 274 en
dc.identifier.issn 0266-8254
dc.identifier.issn 1472-765X
dc.identifier.uri http://hdl.handle.net/10468/116
dc.identifier.doi 10.1111/j.1472-765X.2008.02416.x
dc.description.abstract Aims: Recent evidence suggests that the human gastric microbiota is much more diverse than previously thought. The aim of this study was to assess the potential for isolating lactobacilli from the human stomach.Methods and Results: Lactobacilli were selectively cultured from gastric biopsies from 12 patients undergoing routine endoscopy. Lactobacilli were present in four of 12 biopsies. We isolated, in total 10 different strains representing five species (Lactobacillus gasseri, L. fermentum, L. vaginalis, L. reuteri and L. salivarius). The 10 isolates varied greatly in their ability to inhibit the growth of two Gram-positive bacteria and two Gram-negative bacteria. Furthermore, the acid and bile resistance profiles of the 10 isolates spanned a wide range. Conclusions: Five different Lactobacillus species were cultured from human gastric biopsies for the first time. Significance and Impact of the Study: Diverse Lactobacillus species are more prevalent in the human stomach than previously recognized, representing an untapped source of bacteria with beneficial probiotic and/or biotechnological properties. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Society for Applied Bacteriology; Blackwell Publishing en
dc.rights © 2010 The Society for Applied Microbiology. The definitive version is available at www.blackwell-synergy.com en
dc.rights.uri www.blackwell-synergy.com
dc.subject Helicobacter pylori en
dc.subject Bile en
dc.subject Stomach en
dc.subject Acid en
dc.subject Lactobacilli en
dc.subject Probiotics en
dc.subject.lcsh Lactobacillus en
dc.subject.lcsh Gastrointestinal system -- Microbiology en
dc.title Isolation of Lactobacilli with probiotic properties from the human stomach en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Eamon M. Quigley, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. E-mail: e.quigley@ucc.ie en
dc.internal.authorcontactother Paul O'Toole, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. Email: pwotoole@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2010-02-12T18:14:50Z
dc.description.version Accepted Version en
dc.internal.rssid 722849
dc.internal.wokid 173286400
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Irish Research Council for Science Engineering and Technology en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Letters In Applied Microbiology en
dc.internal.IRISemailaddress e.quigley@ucc.ie en


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