Anakinra for recalcitrant pyoderma gangrenosum

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Anakinra for recalcitrant pyoderma gangrenosum

O'Connor, Cathal; Gallagher, Catriona; Hollywood, Aoife; Paul, Lindsay; O'Connell, Michael
Date: 2021-06-16
Copyright: © 2021, the Authors. Clinical and Experimental Dermatology published by John Wiley & Sons Ltd on behalf of the British Association of Dermatologists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Copyright information: https://creativecommons.org/licenses/by/4.0/
Citation: O'Connor, C., Gallagher, C., Hollywood, A., Paul, L. and O'Connell, M. (2021) 'Anakinra for recalcitrant pyoderma gangrenosum', Clinical and Experimental Dermatology. doi: 10.1111/ced.14809
Published Version: 10.1111/ced.14809

Abstract:

Pyoderma gangrenosum (PG) is an autoinflammatory neutrophilic dermatosis characterized by rapidly enlarging, painful ulcers. Anakinra is a recombinant interleukin-1 (IL-1) receptor antagonist that blocks the activity of IL-1α and IL-1β by competitively inhibiting IL-1 binding to the IL-1 type I receptor. We present a series of two patients with recalcitrant PG, who had limited therapeutic options due to multiple previous treatment failures and multiple co-morbidities, who obtained 100% healing with anakinra. Compared to conventional first-line therapies for PG, the safety profile of anakinra may be preferable for patients with multiple co-morbidities. Further research is needed to assess the safety and efficacy of anakinra for PG.

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© 2021, the Authors. Clinical and Experimental Dermatology published by John Wiley & Sons Ltd on behalf of the British Association of Dermatologists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © 2021, the Authors. Clinical and Experimental Dermatology published by John Wiley & Sons Ltd on behalf of the British Association of Dermatologists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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