Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome
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Published Version
Date
2022-08-23
Authors
Brignoli, Tarcisio
Recker, Mario
Lee, Winnie W. Y.
Dong, Tim
Bhamber, Ranjeet
Albur, Mahableshwar
Williams, Philip
Dowsey, Andrew W.
Massey, Ruth C.
Journal Title
Journal ISSN
Volume Title
Publisher
Microbiology Society
Published Version
Abstract
Staphylococcus aureus bacteraemia (SAB) is a major cause of blood-stream infection (BSI) in both healthcare and community settings. While the underlying comorbidities of a patient significantly contributes to their susceptibility to and outcome following SAB, recent studies show the importance of the level of cytolytic toxin production by the infecting bacterium. In this study we demonstrate that this cytotoxicity can be determined directly from the diagnostic MALDI-TOF mass spectrum generated in a routine diagnostic laboratory. With further development this information could be used to guide the management and improve the outcomes for SAB patients.
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Keywords
Agr , Bacteraemia , MALDI-TOF MS diagnosis , Staphylococcus aureus , Toxicity
Citation
Brignoli, T., Recker, M., Lee, W. W. Y., Dong, T., Bhamber, R., Albur, M., Williams, P., Dowsey, A. W., Massey, Ruth C. (2022) 'Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome'. Microbiology, 168(8), 001223 (6pp). doi: 10.1099/mic.0.001223