Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain

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dc.contributor.author Carroll, Siobhan Y.
dc.contributor.author O'Mahony, Siobhain M.
dc.contributor.author Grenham, Susan
dc.contributor.author Cryan, John F. en
dc.contributor.author Hyland, Niall P.
dc.date.accessioned 2016-02-17T11:44:41Z
dc.date.available 2016-02-17T11:44:41Z
dc.date.issued 2013
dc.identifier.citation Carroll SY, O’Mahony SM, Grenham S, Cryan JF, Hyland NP (2013) Disodium Cromoglycate Reverses Colonic Visceral Hypersensitivity and Influences Colonic Ion Transport in a Stress-Sensitive Rat Strain. PLoS ONE 8(12): e84718. doi:10.1371/journal.pone.0084718
dc.identifier.volume 8 en
dc.identifier.issued 12 en
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10468/2347
dc.identifier.doi 10.1371/journal.pone.0084718
dc.description.abstract The interface between psychiatry and stress-related gastrointestinal disorders (GI), such as irritable bowel syndrome (IBS), is well established, with anxiety and depression the most frequently occurring comorbid conditions. Moreover, stress-sensitive Wistar Kyoto (WKY) rats, which display anxiety-and depressive-like behaviors, exhibit GI disturbances akin to those observed in stress-related GI disorders. Additionally, there is mounting preclinical and clinical evidence implicating mast cells as significant contributors to the development of abdominal visceral pain in IBS. In this study we examined the effects of the rat connective tissue mast cell (CTMC) stabiliser, disodium cromoglycate (DSCG) on visceral hypersensitivity and colonic ion transport, and examined both colonic and peritoneal mast cells from stress-sensitive WKY rats. DSCG significantly decreased abdominal pain behaviors induced by colorectal distension in WKY animals independent of a reduction in colonic rat mast cell mediator release. We further demonstrated that mast cell-stimulated colonic ion transport was sensitive to inhibition by the mast cell stabiliser DSCG, an effect only observed in stress-sensitive rats. Moreover, CTMC-like mast cells were significantly increased in the colonic submucosa of WKY animals, and we observed a significant increase in the proportion of intermediate, or immature, peritoneal mast cells relative to control animals. Collectively our data further support a role for mast cells in the pathogenesis of stress-related GI disorders. en
dc.description.sponsorship Science Foundation Ireland (SFI Grant No. 02/CE/B124; 07/CE/B1368) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Public Library of Science en
dc.rights © 2015 Carroll et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Irritable bowel syndrome en
dc.subject Peritoneal mast cells en
dc.subject Neonatal maternal deprivation en
dc.subject Induced histamine release en
dc.subject Connective tissue type en
dc.subject Long-term alterations en
dc.subject Sodium cromoglycate en
dc.subject Antiallergic compounds en
dc.subject Restraint stress en
dc.subject In vitro en
dc.title Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Niall Hyland, Pharmacology and Therapeutics, University College Cork, Cork, Ireland. +353-21-490-3000 Email: n.hyland@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.rssid 243942593
dc.internal.wokid WOS:000328740300157
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle PLOS ONE en
dc.internal.IRISemailaddress n.hyland@ucc.ie en
dc.identifier.articleid UNSP e84718


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© 2015 Carroll et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Except where otherwise noted, this item's license is described as © 2015 Carroll et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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