Wounds that heal and wounds that don't - The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis

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dc.contributor.author Millar, Neal L.
dc.contributor.author O'Donnell, Charlotte
dc.contributor.author McInnes, Iain B.
dc.contributor.author Brint, Elizabeth K.
dc.date.accessioned 2016-10-10T11:06:44Z
dc.date.available 2016-10-10T11:06:44Z
dc.date.issued 2016-08
dc.identifier.citation Millar, N. L., O’Donnell, C., McInnes, I. B. and Brint, E. (2017) ‘Wounds that heal and wounds that don’t − The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis’, Seminars in Cell and Developmental Biology, 61, pp. 41-50. doi: 10.1016/j.semcdb.2016.08.007 en
dc.identifier.volume 61
dc.identifier.startpage 41
dc.identifier.endpage 50
dc.identifier.issn 1096-3634
dc.identifier.uri http://hdl.handle.net/10468/3170
dc.identifier.doi 10.1016/j.semcdb.2016.08.007
dc.description.abstract IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell where it can interact with its receptor ST2, triggering danger-associated responses and act as a cellular "alarmin". Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in promoting wound healing has also emerged in multiple tissues types. This review will explore the current literature concerning this homeostatic role of IL-33/ST2 in tissue repair and also review its role in uncontrolled wound responses as seen in both fibrosis and tumorigenesis. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S1084952116302452
dc.rights © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Interleukin 33 en
dc.subject Tumorigenesis en
dc.subject Fibrosis en
dc.subject Tissue damage en
dc.subject ST2 en
dc.title Wounds that heal and wounds that don't - The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Beth Brint, Pathology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: e.brint@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by the request of the publisher. en
dc.check.date 2017-08-10
dc.date.updated 2016-10-10T10:56:39Z
dc.description.version Accepted Version en
dc.internal.rssid 367377327
dc.internal.pmid 27521518
dc.description.status Peer reviewed en
dc.identifier.journaltitle Seminars in Cell & Developmental Biology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress e.brint@ucc.ie en


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© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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