Wounds that heal and wounds that don't - The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis

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dc.contributor.authorMillar, Neal L.
dc.contributor.authorO'Donnell, Charlotte
dc.contributor.authorMcInnes, Iain B.
dc.contributor.authorBrint, Elizabeth K.
dc.date.accessioned2016-10-10T11:06:44Z
dc.date.available2016-10-10T11:06:44Z
dc.date.issued2016-08
dc.date.updated2016-10-10T10:56:39Z
dc.description.abstractIL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell where it can interact with its receptor ST2, triggering danger-associated responses and act as a cellular "alarmin". Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in promoting wound healing has also emerged in multiple tissues types. This review will explore the current literature concerning this homeostatic role of IL-33/ST2 in tissue repair and also review its role in uncontrolled wound responses as seen in both fibrosis and tumorigenesis.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMillar, N. L., O’Donnell, C., McInnes, I. B. and Brint, E. (2017) ‘Wounds that heal and wounds that don’t − The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis’, Seminars in Cell and Developmental Biology, 61, pp. 41-50. doi: 10.1016/j.semcdb.2016.08.007en
dc.identifier.doi10.1016/j.semcdb.2016.08.007
dc.identifier.endpage50
dc.identifier.issn1096-3634
dc.identifier.journaltitleSeminars in Cell & Developmental Biologyen
dc.identifier.startpage41
dc.identifier.urihttps://hdl.handle.net/10468/3170
dc.identifier.volume61
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S1084952116302452
dc.rights© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 licenseen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectInterleukin 33en
dc.subjectTumorigenesisen
dc.subjectFibrosisen
dc.subjectTissue damageen
dc.subjectST2en
dc.titleWounds that heal and wounds that don't - The role of the IL-33/ST2 pathway in tissue repair and tumorigenesisen
dc.typeArticle (peer-reviewed)en
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