Wounds that heal and wounds that don't - The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis

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Millar, Neal L.
O'Donnell, Charlotte
McInnes, Iain B.
Brint, Elizabeth K.
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IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell where it can interact with its receptor ST2, triggering danger-associated responses and act as a cellular "alarmin". Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in promoting wound healing has also emerged in multiple tissues types. This review will explore the current literature concerning this homeostatic role of IL-33/ST2 in tissue repair and also review its role in uncontrolled wound responses as seen in both fibrosis and tumorigenesis.
Interleukin 33 , Tumorigenesis , Fibrosis , Tissue damage , ST2
Millar, N. L., O’Donnell, C., McInnes, I. B. and Brint, E. (2017) ‘Wounds that heal and wounds that don’t − The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis’, Seminars in Cell and Developmental Biology, 61, pp. 41-50. doi: 10.1016/j.semcdb.2016.08.007