Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat

Show simple item record

dc.contributor.author McDonald, Fiona B.
dc.contributor.author Dempsey, Eugene M.
dc.contributor.author O'Halloran, Ken D.
dc.date.accessioned 2017-01-04T16:20:04Z
dc.date.available 2017-01-04T16:20:04Z
dc.date.issued 2016-07-12
dc.identifier.citation McDonald, F. B., Dempsey, E. M. and O'Halloran, K. D. (2016) 'Effects of Gestational and Postnatal Exposure to Chronic Intermittent Hypoxia on Diaphragm Muscle Contractile Function in the Rat', Frontiers in Physiology, 7, 276 (10 pp). doi: 10.3389/fphys.2016.00276 en
dc.identifier.volume 7 en
dc.identifier.startpage 276-1 en
dc.identifier.endpage 276-10 en
dc.identifier.issn 1664-042X
dc.identifier.uri http://hdl.handle.net/10468/3426
dc.identifier.doi 10.3389/fphys.2016.00276
dc.description.abstract Alterations to the supply of oxygen during early life presents a profound stressor to physiological systems with aberrant remodeling that is often long-lasting. Chronic intermittent hypoxia (CIH) is a feature of apnea of prematurity, chronic lung disease, and sleep apnea. CIH affects respiratory control but there is a dearth of information concerning the effects of CIH on respiratory muscles, including the diaphragm—the major pump muscle of breathing. We investigated the effects of exposure to gestational CIH (gCIH) and postnatal CIH (pCIH) on diaphragm muscle function in male and female rats. CIH consisted of exposure in environmental chambers to 90 s of hypoxia reaching 5% O2 at nadir, once every 5 min, 8 h a day. Exposure to gCIH started within 24 h of identification of a copulation plug and continued until day 20 of gestation; animals were studied on postnatal day 22 or 42. For pCIH, pups were born in normoxia and within 24 h of delivery were exposed with dams to CIH for 3 weeks; animals were studied on postnatal day 22 or 42. Sham groups were exposed to normoxia in parallel. Following gas exposures, diaphragm muscle contractile, and endurance properties were examined ex vivo. Neither gCIH nor pCIH exposure had effects on diaphragm muscle force-generating capacity or endurance in either sex. Similarly, early life exposure to CIH did not affect muscle tolerance of severe hypoxic stress determined ex vivo. The findings contrast with our recent observation of upper airway dilator muscle weakness following exposure to pCIH. Thus, the present study suggests a relative resilience to hypoxic stress in diaphragm muscle. Co-ordinated activity of thoracic pump and upper airway dilator muscles is required for optimal control of upper airway caliber. A mismatch in the force-generating capacity of the complementary muscle groups could have adverse consequences for the control of airway patency and respiratory homeostasis. en
dc.description.sponsorship University College Dublin (School of Medicine and Medical Science)
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.rights © 2016 McDonald, Dempsey and O’Halloran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Development en
dc.subject Early life stress en
dc.subject Perinatal en
dc.subject Respiratory muscle en
dc.subject Hypoxia en
dc.title Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ken O'Halloran, Physiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: k.ohalloran@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-01-04T16:14:27Z
dc.description.version Published Version en
dc.internal.rssid 351591029
dc.internal.rssid 395506622
dc.contributor.funder Health Research Board en
dc.contributor.funder University College Dublin en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Physiology en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress g.dempsey@ucc.ie
dc.internal.IRISemailaddress k.ohalloran@ucc.ie en
dc.internal.IRISemailaddress fiona.mcdonald@ucc.ie en


Files in this item

This item appears in the following Collection(s)

Show simple item record

© 2016 McDonald, Dempsey and O’Halloran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2016 McDonald, Dempsey and O’Halloran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement